Insulin Resistance Predicts Mortality in Nondiabetic Individuals in the U.S.
OBJECTIVE: Insulin resistance is a suspected causative factor in a wide variety of diseases. We aimed to determine whether insulin resistance, estimated by the homeostasis model assessment for insulin resistance (HOMA-IR), is associated with all-cause or disease-specific mortality among nondiabetic...
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Formato: | Texto |
Lenguaje: | English |
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American Diabetes Association
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2875420/ https://www.ncbi.nlm.nih.gov/pubmed/20200308 http://dx.doi.org/10.2337/dc09-2110 |
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author | Ausk, Karlee J. Boyko, Edward J. Ioannou, George N. |
author_facet | Ausk, Karlee J. Boyko, Edward J. Ioannou, George N. |
author_sort | Ausk, Karlee J. |
collection | PubMed |
description | OBJECTIVE: Insulin resistance is a suspected causative factor in a wide variety of diseases. We aimed to determine whether insulin resistance, estimated by the homeostasis model assessment for insulin resistance (HOMA-IR), is associated with all-cause or disease-specific mortality among nondiabetic persons in the U.S. RESEARCH DESIGN AND METHODS: We determined the association between HOMA-IR and death certificate–based mortality among 5,511 nondiabetic, adult participants of the third U.S. National Health and Nutrition Examination Survey (1988–1994) during up to 12 years of follow-up, after adjustment for potential confounders (age, sex, BMI, waist-to-hip ratio, alcohol consumption, race/ethnicity, educational attainment, smoking status, physical activity, C-reactive protein, systolic and diastolic blood pressure, plasma total and HDL cholesterol, and triglycerides). RESULTS: HOMA-IR was significantly associated with all-cause mortality (adjusted hazard ratio 1.16 [95% CI 1.01–1.3], comparing successive quartiles of HOMA-IR in a linear model and 1.64 [1.1–2.5], comparing the top [HOMA-IR >2.8] to the bottom [HOMA-IR ≤1.4] quartile). HOMA-IR was significantly associated with all-cause mortality only in subjects with BMI <25.2 kg/m(2) (the median value) but not in subjects with BMI ≥25.2 kg/m(2). Subjects in the second, third, and fourth quartile of HOMA-IR appeared to have higher cardiovascular mortality than subjects in the lowest quartile of HOMA-IR. HOMA-IR was not associated with cancer-related mortality. CONCLUSIONS: HOMA-IR is associated with all-cause mortality in the nondiabetic U.S. population but only among persons with normal BMI. HOMA-IR is a readily available measure that can be used in the future to predict mortality in clinical or epidemiological settings. |
format | Text |
id | pubmed-2875420 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | American Diabetes Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-28754202011-06-01 Insulin Resistance Predicts Mortality in Nondiabetic Individuals in the U.S. Ausk, Karlee J. Boyko, Edward J. Ioannou, George N. Diabetes Care Original Research OBJECTIVE: Insulin resistance is a suspected causative factor in a wide variety of diseases. We aimed to determine whether insulin resistance, estimated by the homeostasis model assessment for insulin resistance (HOMA-IR), is associated with all-cause or disease-specific mortality among nondiabetic persons in the U.S. RESEARCH DESIGN AND METHODS: We determined the association between HOMA-IR and death certificate–based mortality among 5,511 nondiabetic, adult participants of the third U.S. National Health and Nutrition Examination Survey (1988–1994) during up to 12 years of follow-up, after adjustment for potential confounders (age, sex, BMI, waist-to-hip ratio, alcohol consumption, race/ethnicity, educational attainment, smoking status, physical activity, C-reactive protein, systolic and diastolic blood pressure, plasma total and HDL cholesterol, and triglycerides). RESULTS: HOMA-IR was significantly associated with all-cause mortality (adjusted hazard ratio 1.16 [95% CI 1.01–1.3], comparing successive quartiles of HOMA-IR in a linear model and 1.64 [1.1–2.5], comparing the top [HOMA-IR >2.8] to the bottom [HOMA-IR ≤1.4] quartile). HOMA-IR was significantly associated with all-cause mortality only in subjects with BMI <25.2 kg/m(2) (the median value) but not in subjects with BMI ≥25.2 kg/m(2). Subjects in the second, third, and fourth quartile of HOMA-IR appeared to have higher cardiovascular mortality than subjects in the lowest quartile of HOMA-IR. HOMA-IR was not associated with cancer-related mortality. CONCLUSIONS: HOMA-IR is associated with all-cause mortality in the nondiabetic U.S. population but only among persons with normal BMI. HOMA-IR is a readily available measure that can be used in the future to predict mortality in clinical or epidemiological settings. American Diabetes Association 2010-06 2010-03-03 /pmc/articles/PMC2875420/ /pubmed/20200308 http://dx.doi.org/10.2337/dc09-2110 Text en © 2010 by the American Diabetes Association. https://creativecommons.org/licenses/by-nc-nd/3.0/Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ (https://creativecommons.org/licenses/by-nc-nd/3.0/) for details. |
spellingShingle | Original Research Ausk, Karlee J. Boyko, Edward J. Ioannou, George N. Insulin Resistance Predicts Mortality in Nondiabetic Individuals in the U.S. |
title | Insulin Resistance Predicts Mortality in Nondiabetic Individuals in the U.S. |
title_full | Insulin Resistance Predicts Mortality in Nondiabetic Individuals in the U.S. |
title_fullStr | Insulin Resistance Predicts Mortality in Nondiabetic Individuals in the U.S. |
title_full_unstemmed | Insulin Resistance Predicts Mortality in Nondiabetic Individuals in the U.S. |
title_short | Insulin Resistance Predicts Mortality in Nondiabetic Individuals in the U.S. |
title_sort | insulin resistance predicts mortality in nondiabetic individuals in the u.s. |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2875420/ https://www.ncbi.nlm.nih.gov/pubmed/20200308 http://dx.doi.org/10.2337/dc09-2110 |
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