Insulin Resistance Predicts Mortality in Nondiabetic Individuals in the U.S.

OBJECTIVE: Insulin resistance is a suspected causative factor in a wide variety of diseases. We aimed to determine whether insulin resistance, estimated by the homeostasis model assessment for insulin resistance (HOMA-IR), is associated with all-cause or disease-specific mortality among nondiabetic...

Descripción completa

Detalles Bibliográficos
Autores principales: Ausk, Karlee J., Boyko, Edward J., Ioannou, George N.
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2875420/
https://www.ncbi.nlm.nih.gov/pubmed/20200308
http://dx.doi.org/10.2337/dc09-2110
_version_ 1782181568514621440
author Ausk, Karlee J.
Boyko, Edward J.
Ioannou, George N.
author_facet Ausk, Karlee J.
Boyko, Edward J.
Ioannou, George N.
author_sort Ausk, Karlee J.
collection PubMed
description OBJECTIVE: Insulin resistance is a suspected causative factor in a wide variety of diseases. We aimed to determine whether insulin resistance, estimated by the homeostasis model assessment for insulin resistance (HOMA-IR), is associated with all-cause or disease-specific mortality among nondiabetic persons in the U.S. RESEARCH DESIGN AND METHODS: We determined the association between HOMA-IR and death certificate–based mortality among 5,511 nondiabetic, adult participants of the third U.S. National Health and Nutrition Examination Survey (1988–1994) during up to 12 years of follow-up, after adjustment for potential confounders (age, sex, BMI, waist-to-hip ratio, alcohol consumption, race/ethnicity, educational attainment, smoking status, physical activity, C-reactive protein, systolic and diastolic blood pressure, plasma total and HDL cholesterol, and triglycerides). RESULTS: HOMA-IR was significantly associated with all-cause mortality (adjusted hazard ratio 1.16 [95% CI 1.01–1.3], comparing successive quartiles of HOMA-IR in a linear model and 1.64 [1.1–2.5], comparing the top [HOMA-IR >2.8] to the bottom [HOMA-IR ≤1.4] quartile). HOMA-IR was significantly associated with all-cause mortality only in subjects with BMI <25.2 kg/m(2) (the median value) but not in subjects with BMI ≥25.2 kg/m(2). Subjects in the second, third, and fourth quartile of HOMA-IR appeared to have higher cardiovascular mortality than subjects in the lowest quartile of HOMA-IR. HOMA-IR was not associated with cancer-related mortality. CONCLUSIONS: HOMA-IR is associated with all-cause mortality in the nondiabetic U.S. population but only among persons with normal BMI. HOMA-IR is a readily available measure that can be used in the future to predict mortality in clinical or epidemiological settings.
format Text
id pubmed-2875420
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher American Diabetes Association
record_format MEDLINE/PubMed
spelling pubmed-28754202011-06-01 Insulin Resistance Predicts Mortality in Nondiabetic Individuals in the U.S. Ausk, Karlee J. Boyko, Edward J. Ioannou, George N. Diabetes Care Original Research OBJECTIVE: Insulin resistance is a suspected causative factor in a wide variety of diseases. We aimed to determine whether insulin resistance, estimated by the homeostasis model assessment for insulin resistance (HOMA-IR), is associated with all-cause or disease-specific mortality among nondiabetic persons in the U.S. RESEARCH DESIGN AND METHODS: We determined the association between HOMA-IR and death certificate–based mortality among 5,511 nondiabetic, adult participants of the third U.S. National Health and Nutrition Examination Survey (1988–1994) during up to 12 years of follow-up, after adjustment for potential confounders (age, sex, BMI, waist-to-hip ratio, alcohol consumption, race/ethnicity, educational attainment, smoking status, physical activity, C-reactive protein, systolic and diastolic blood pressure, plasma total and HDL cholesterol, and triglycerides). RESULTS: HOMA-IR was significantly associated with all-cause mortality (adjusted hazard ratio 1.16 [95% CI 1.01–1.3], comparing successive quartiles of HOMA-IR in a linear model and 1.64 [1.1–2.5], comparing the top [HOMA-IR >2.8] to the bottom [HOMA-IR ≤1.4] quartile). HOMA-IR was significantly associated with all-cause mortality only in subjects with BMI <25.2 kg/m(2) (the median value) but not in subjects with BMI ≥25.2 kg/m(2). Subjects in the second, third, and fourth quartile of HOMA-IR appeared to have higher cardiovascular mortality than subjects in the lowest quartile of HOMA-IR. HOMA-IR was not associated with cancer-related mortality. CONCLUSIONS: HOMA-IR is associated with all-cause mortality in the nondiabetic U.S. population but only among persons with normal BMI. HOMA-IR is a readily available measure that can be used in the future to predict mortality in clinical or epidemiological settings. American Diabetes Association 2010-06 2010-03-03 /pmc/articles/PMC2875420/ /pubmed/20200308 http://dx.doi.org/10.2337/dc09-2110 Text en © 2010 by the American Diabetes Association. https://creativecommons.org/licenses/by-nc-nd/3.0/Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ (https://creativecommons.org/licenses/by-nc-nd/3.0/) for details.
spellingShingle Original Research
Ausk, Karlee J.
Boyko, Edward J.
Ioannou, George N.
Insulin Resistance Predicts Mortality in Nondiabetic Individuals in the U.S.
title Insulin Resistance Predicts Mortality in Nondiabetic Individuals in the U.S.
title_full Insulin Resistance Predicts Mortality in Nondiabetic Individuals in the U.S.
title_fullStr Insulin Resistance Predicts Mortality in Nondiabetic Individuals in the U.S.
title_full_unstemmed Insulin Resistance Predicts Mortality in Nondiabetic Individuals in the U.S.
title_short Insulin Resistance Predicts Mortality in Nondiabetic Individuals in the U.S.
title_sort insulin resistance predicts mortality in nondiabetic individuals in the u.s.
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2875420/
https://www.ncbi.nlm.nih.gov/pubmed/20200308
http://dx.doi.org/10.2337/dc09-2110
work_keys_str_mv AT auskkarleej insulinresistancepredictsmortalityinnondiabeticindividualsintheus
AT boykoedwardj insulinresistancepredictsmortalityinnondiabeticindividualsintheus
AT ioannougeorgen insulinresistancepredictsmortalityinnondiabeticindividualsintheus