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Long-Term Trends in Cardiorespiratory Fitness and the Incidence of Type 2 Diabetes

OBJECTIVE: Whereas single assessments of cardiorespiratory fitness have been shown to predict lower incidence of type 2 diabetes, there are no data on long-term trends in fitness and risk. We investigated the relationship between long-term trends in fitness and the incidence of type 2 diabetes. RESE...

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Autores principales: Sawada, Susumu S., Lee, I.-Min, Naito, Hisashi, Noguchi, Jun, Tsukamoto, Koji, Muto, Takashi, Higaki, Yasuki, Tanaka, Hiroaki, Blair, Steven N.
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2875453/
https://www.ncbi.nlm.nih.gov/pubmed/20215460
http://dx.doi.org/10.2337/dc09-1654
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author Sawada, Susumu S.
Lee, I.-Min
Naito, Hisashi
Noguchi, Jun
Tsukamoto, Koji
Muto, Takashi
Higaki, Yasuki
Tanaka, Hiroaki
Blair, Steven N.
author_facet Sawada, Susumu S.
Lee, I.-Min
Naito, Hisashi
Noguchi, Jun
Tsukamoto, Koji
Muto, Takashi
Higaki, Yasuki
Tanaka, Hiroaki
Blair, Steven N.
author_sort Sawada, Susumu S.
collection PubMed
description OBJECTIVE: Whereas single assessments of cardiorespiratory fitness have been shown to predict lower incidence of type 2 diabetes, there are no data on long-term trends in fitness and risk. We investigated the relationship between long-term trends in fitness and the incidence of type 2 diabetes. RESEARCH DESIGN AND METHODS: A cohort of 4,187 Japanese men free of diabetes completed annual health checkups and fitness tests for estimated maximal oxygen uptake at least four times over 7 years (1979–1985). We modeled the trend in fitness over 7 years for each man using simple linear regression. Men were then divided into quartiles based on the regression coefficient (slope) from the model. During the follow-up period (1985–1999), 274 men developed diabetes. Hazard ratios (HRs) and 95% CIs for the incidence of diabetes were obtained using the Cox proportional hazards model. RESULTS: Men in the lowest quartile of the distribution decreased in fitness over the 7 years (median slope −1.25 ml/kg/min), whereas men in the highest quartile increased in fitness (median slope 1.33 ml/kg/min). With adjustment for age, initial fitness level, BMI, systolic blood pressure, cigarette smoking, alcohol intake, and a family history of diabetes and use of the lowest quartile, the HRs (95% CI) for the second through fourth quartiles were 0.64 (0.46–0.89), 0.40 (0.27–0.58), and 0.33 (0.21–0.50), respectively (P(trend) < 0.001). CONCLUSIONS: These results indicate that the long-term trend in fitness is a strong predictor of the incidence of type 2 diabetes in Japanese men.
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spelling pubmed-28754532011-06-01 Long-Term Trends in Cardiorespiratory Fitness and the Incidence of Type 2 Diabetes Sawada, Susumu S. Lee, I.-Min Naito, Hisashi Noguchi, Jun Tsukamoto, Koji Muto, Takashi Higaki, Yasuki Tanaka, Hiroaki Blair, Steven N. Diabetes Care Original Research OBJECTIVE: Whereas single assessments of cardiorespiratory fitness have been shown to predict lower incidence of type 2 diabetes, there are no data on long-term trends in fitness and risk. We investigated the relationship between long-term trends in fitness and the incidence of type 2 diabetes. RESEARCH DESIGN AND METHODS: A cohort of 4,187 Japanese men free of diabetes completed annual health checkups and fitness tests for estimated maximal oxygen uptake at least four times over 7 years (1979–1985). We modeled the trend in fitness over 7 years for each man using simple linear regression. Men were then divided into quartiles based on the regression coefficient (slope) from the model. During the follow-up period (1985–1999), 274 men developed diabetes. Hazard ratios (HRs) and 95% CIs for the incidence of diabetes were obtained using the Cox proportional hazards model. RESULTS: Men in the lowest quartile of the distribution decreased in fitness over the 7 years (median slope −1.25 ml/kg/min), whereas men in the highest quartile increased in fitness (median slope 1.33 ml/kg/min). With adjustment for age, initial fitness level, BMI, systolic blood pressure, cigarette smoking, alcohol intake, and a family history of diabetes and use of the lowest quartile, the HRs (95% CI) for the second through fourth quartiles were 0.64 (0.46–0.89), 0.40 (0.27–0.58), and 0.33 (0.21–0.50), respectively (P(trend) < 0.001). CONCLUSIONS: These results indicate that the long-term trend in fitness is a strong predictor of the incidence of type 2 diabetes in Japanese men. American Diabetes Association 2010-06 2010-03-09 /pmc/articles/PMC2875453/ /pubmed/20215460 http://dx.doi.org/10.2337/dc09-1654 Text en © 2010 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.
spellingShingle Original Research
Sawada, Susumu S.
Lee, I.-Min
Naito, Hisashi
Noguchi, Jun
Tsukamoto, Koji
Muto, Takashi
Higaki, Yasuki
Tanaka, Hiroaki
Blair, Steven N.
Long-Term Trends in Cardiorespiratory Fitness and the Incidence of Type 2 Diabetes
title Long-Term Trends in Cardiorespiratory Fitness and the Incidence of Type 2 Diabetes
title_full Long-Term Trends in Cardiorespiratory Fitness and the Incidence of Type 2 Diabetes
title_fullStr Long-Term Trends in Cardiorespiratory Fitness and the Incidence of Type 2 Diabetes
title_full_unstemmed Long-Term Trends in Cardiorespiratory Fitness and the Incidence of Type 2 Diabetes
title_short Long-Term Trends in Cardiorespiratory Fitness and the Incidence of Type 2 Diabetes
title_sort long-term trends in cardiorespiratory fitness and the incidence of type 2 diabetes
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2875453/
https://www.ncbi.nlm.nih.gov/pubmed/20215460
http://dx.doi.org/10.2337/dc09-1654
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