Oxygen consumption is depressed in patients with lactic acidosis due to biguanide intoxication

INTRODUCTION: Lactic acidosis can develop during biguanide (metformin and phenformin) intoxication, possibly as a consequence of mitochondrial dysfunction. To verify this hypothesis, we investigated whether body oxygen consumption (VO(2)), that primarily depends on mitochondrial respiration, is depr...

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Detalles Bibliográficos
Autores principales: Protti, Alessandro, Russo, Riccarda, Tagliabue, Paola, Vecchio, Sarah, Singer, Mervyn, Rudiger, Alain, Foti, Giuseppe, Rossi, Anna, Mistraletti, Giovanni, Gattinoni, Luciano
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2875537/
https://www.ncbi.nlm.nih.gov/pubmed/20170489
http://dx.doi.org/10.1186/cc8885

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