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Hypertension and hyperparathyroidism are associated with left ventricular hypertrophy in patients on hemodialysis
Conflicting data for association between left ventricular hypertrophy (LVH) and secondary hyperparathyroidism has been reported previously among dialysis patients. The present study was conducted to evaluate the association of hyperparathyroidism and hypertension with LVH. Charts of 130 patients on...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2875705/ https://www.ncbi.nlm.nih.gov/pubmed/20535251 http://dx.doi.org/10.4103/0971-4065.59337 |
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author | Al-Hilali, N. Hussain, N. Ataia, A. I. Al-Azmi, M. Al-Helal, B. Johny, K. V. |
author_facet | Al-Hilali, N. Hussain, N. Ataia, A. I. Al-Azmi, M. Al-Helal, B. Johny, K. V. |
author_sort | Al-Hilali, N. |
collection | PubMed |
description | Conflicting data for association between left ventricular hypertrophy (LVH) and secondary hyperparathyroidism has been reported previously among dialysis patients. The present study was conducted to evaluate the association of hyperparathyroidism and hypertension with LVH. Charts of 130 patients on hemodialysis for at least six months were reviewed. All were subjected to M-mode echocardiography. Left ventricular mass (LVM) was calculated by Devereux's formula. LVM Index (LVMI) was calculated by dividing LVM by body surface area. Sera were analyzed for intact parathyroid hormone (iPTH). iPTH of > 32 pmol/l and a mean blood pressure (MAP) of > 107 mmHg were considered high. Patients were stratified into groups according to their MAP and iPTH. A total of (47.7%) patients were males and 68 (52.3%) were females. Their median age was 57 years. The median duration on dialysis was 26 months. Forty eight (36.9%) patients had high BP and 54 (41.5%) had high iPTH. Both high BP and high iPTH were present in 38 (29.2%) patients. Analysis of the relationship between LVM, LVMI, MAP and iPTH showed that LVM and LVMI were significantly (P < 0.001) higher in patients with concomitant high BP and high iPTH. LVMI was significantly higher in patients with high iPTH alone. Concomitant high iPTH and high MAP increase the risk of LVH in hemodialysis patients. High iPTH alone might contribute in escalating LVH. Adequate control of hypertension and hyperparathyroidism might reduce the risk of developing LVH. |
format | Text |
id | pubmed-2875705 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Medknow Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-28757052010-06-09 Hypertension and hyperparathyroidism are associated with left ventricular hypertrophy in patients on hemodialysis Al-Hilali, N. Hussain, N. Ataia, A. I. Al-Azmi, M. Al-Helal, B. Johny, K. V. Indian J Nephrol Original Article Conflicting data for association between left ventricular hypertrophy (LVH) and secondary hyperparathyroidism has been reported previously among dialysis patients. The present study was conducted to evaluate the association of hyperparathyroidism and hypertension with LVH. Charts of 130 patients on hemodialysis for at least six months were reviewed. All were subjected to M-mode echocardiography. Left ventricular mass (LVM) was calculated by Devereux's formula. LVM Index (LVMI) was calculated by dividing LVM by body surface area. Sera were analyzed for intact parathyroid hormone (iPTH). iPTH of > 32 pmol/l and a mean blood pressure (MAP) of > 107 mmHg were considered high. Patients were stratified into groups according to their MAP and iPTH. A total of (47.7%) patients were males and 68 (52.3%) were females. Their median age was 57 years. The median duration on dialysis was 26 months. Forty eight (36.9%) patients had high BP and 54 (41.5%) had high iPTH. Both high BP and high iPTH were present in 38 (29.2%) patients. Analysis of the relationship between LVM, LVMI, MAP and iPTH showed that LVM and LVMI were significantly (P < 0.001) higher in patients with concomitant high BP and high iPTH. LVMI was significantly higher in patients with high iPTH alone. Concomitant high iPTH and high MAP increase the risk of LVH in hemodialysis patients. High iPTH alone might contribute in escalating LVH. Adequate control of hypertension and hyperparathyroidism might reduce the risk of developing LVH. Medknow Publications 2009-10 /pmc/articles/PMC2875705/ /pubmed/20535251 http://dx.doi.org/10.4103/0971-4065.59337 Text en © Indian Journal of Nephrology http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Al-Hilali, N. Hussain, N. Ataia, A. I. Al-Azmi, M. Al-Helal, B. Johny, K. V. Hypertension and hyperparathyroidism are associated with left ventricular hypertrophy in patients on hemodialysis |
title | Hypertension and hyperparathyroidism are associated with left ventricular hypertrophy in patients on hemodialysis |
title_full | Hypertension and hyperparathyroidism are associated with left ventricular hypertrophy in patients on hemodialysis |
title_fullStr | Hypertension and hyperparathyroidism are associated with left ventricular hypertrophy in patients on hemodialysis |
title_full_unstemmed | Hypertension and hyperparathyroidism are associated with left ventricular hypertrophy in patients on hemodialysis |
title_short | Hypertension and hyperparathyroidism are associated with left ventricular hypertrophy in patients on hemodialysis |
title_sort | hypertension and hyperparathyroidism are associated with left ventricular hypertrophy in patients on hemodialysis |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2875705/ https://www.ncbi.nlm.nih.gov/pubmed/20535251 http://dx.doi.org/10.4103/0971-4065.59337 |
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