Gold nanoparticle–choline complexes can block nicotinic acetylcholine receptors

We identified a novel class of direct ion-channel blockers of ligand-gated ion channels called the gold nanoparticle–choline complex. Negatively charged gold nanoparticles (1.4 nm) block ion pores by binding to the sulfur group of the cysteine loop of nicotinic acetylcholine receptors (nAChRs), and...

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Detalles Bibliográficos
Autores principales: Chin, Chur, Kim, In Kyeom, Lim, Dong Yoon, Kim, Ki Suk, Lee, Hyang Ae, Kim, Eun Joo
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2010
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2875724/
https://www.ncbi.nlm.nih.gov/pubmed/20517475

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