Reduced exposure of imatinib after coadministration with acetaminophen in mice

PURPOSE: Imatinib is an efficacious drug against chronic myeloid leukemia (CML) and gastrointestinal stromal tumor (GIST) due to selective inhibition of c-KIT and BCR-ABL kinases. It presents almost complete bioavailability, is eliminated via P450-mediated metabolism and is well tolerated. However,...

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Detalles Bibliográficos
Autores principales: Nassar, Inthisham, Pasupati, Thanikachalam, Judson, John Paul, Segarra, Ignacio
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2875735/
https://www.ncbi.nlm.nih.gov/pubmed/20523867
http://dx.doi.org/10.4103/0253-7613.56071

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2875735/
https://www.ncbi.nlm.nih.gov/pubmed/20523867
http://dx.doi.org/10.4103/0253-7613.56071

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