The Investigation of Effects of Quercetin and Its Combination with Cisplatin on Malignant Mesothelioma Cells In Vitro

Malignant Mesothelioma (MM) is an aggressive and lethal tumour of the serosal surfaces with poor prognosis. In this study, we have investigated the antiproliferative effect of Quercetin (QU) and its combination with Cisplatin (CIS) on SPC212 and SPC111 cell lines. Our experiments showed that QU sign...

Descripción completa

Detalles Bibliográficos
Autores principales: Demiroglu-Zergeroglu, A., Basara-Cigerim, B., Kilic, E., Yanikkaya-Demirel, G.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2875771/
https://www.ncbi.nlm.nih.gov/pubmed/20508819
http://dx.doi.org/10.1155/2010/851589
_version_ 1782181637475270656
author Demiroglu-Zergeroglu, A.
Basara-Cigerim, B.
Kilic, E.
Yanikkaya-Demirel, G.
author_facet Demiroglu-Zergeroglu, A.
Basara-Cigerim, B.
Kilic, E.
Yanikkaya-Demirel, G.
author_sort Demiroglu-Zergeroglu, A.
collection PubMed
description Malignant Mesothelioma (MM) is an aggressive and lethal tumour of the serosal surfaces with poor prognosis. In this study, we have investigated the antiproliferative effect of Quercetin (QU) and its combination with Cisplatin (CIS) on SPC212 and SPC111 cell lines. Our experiments showed that QU significantly reduced the proliferation of cell lines, altered the cell cycle distribution, and increased the level of Caspase 9 (C9) and Caspase 3 (C3) in concentration and time-dependent manner. Additionally, the combination of QU + CIS was found more effective when compared with individual treatment of agents.
format Text
id pubmed-2875771
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-28757712010-05-27 The Investigation of Effects of Quercetin and Its Combination with Cisplatin on Malignant Mesothelioma Cells In Vitro Demiroglu-Zergeroglu, A. Basara-Cigerim, B. Kilic, E. Yanikkaya-Demirel, G. J Biomed Biotechnol Research Article Malignant Mesothelioma (MM) is an aggressive and lethal tumour of the serosal surfaces with poor prognosis. In this study, we have investigated the antiproliferative effect of Quercetin (QU) and its combination with Cisplatin (CIS) on SPC212 and SPC111 cell lines. Our experiments showed that QU significantly reduced the proliferation of cell lines, altered the cell cycle distribution, and increased the level of Caspase 9 (C9) and Caspase 3 (C3) in concentration and time-dependent manner. Additionally, the combination of QU + CIS was found more effective when compared with individual treatment of agents. Hindawi Publishing Corporation 2010 2010-05-17 /pmc/articles/PMC2875771/ /pubmed/20508819 http://dx.doi.org/10.1155/2010/851589 Text en Copyright © 2010 A. Demiroglu-Zergeroglu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Demiroglu-Zergeroglu, A.
Basara-Cigerim, B.
Kilic, E.
Yanikkaya-Demirel, G.
The Investigation of Effects of Quercetin and Its Combination with Cisplatin on Malignant Mesothelioma Cells In Vitro
title The Investigation of Effects of Quercetin and Its Combination with Cisplatin on Malignant Mesothelioma Cells In Vitro
title_full The Investigation of Effects of Quercetin and Its Combination with Cisplatin on Malignant Mesothelioma Cells In Vitro
title_fullStr The Investigation of Effects of Quercetin and Its Combination with Cisplatin on Malignant Mesothelioma Cells In Vitro
title_full_unstemmed The Investigation of Effects of Quercetin and Its Combination with Cisplatin on Malignant Mesothelioma Cells In Vitro
title_short The Investigation of Effects of Quercetin and Its Combination with Cisplatin on Malignant Mesothelioma Cells In Vitro
title_sort investigation of effects of quercetin and its combination with cisplatin on malignant mesothelioma cells in vitro
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2875771/
https://www.ncbi.nlm.nih.gov/pubmed/20508819
http://dx.doi.org/10.1155/2010/851589
work_keys_str_mv AT demirogluzergeroglua theinvestigationofeffectsofquercetinanditscombinationwithcisplatinonmalignantmesotheliomacellsinvitro
AT basaracigerimb theinvestigationofeffectsofquercetinanditscombinationwithcisplatinonmalignantmesotheliomacellsinvitro
AT kilice theinvestigationofeffectsofquercetinanditscombinationwithcisplatinonmalignantmesotheliomacellsinvitro
AT yanikkayademirelg theinvestigationofeffectsofquercetinanditscombinationwithcisplatinonmalignantmesotheliomacellsinvitro
AT demirogluzergeroglua investigationofeffectsofquercetinanditscombinationwithcisplatinonmalignantmesotheliomacellsinvitro
AT basaracigerimb investigationofeffectsofquercetinanditscombinationwithcisplatinonmalignantmesotheliomacellsinvitro
AT kilice investigationofeffectsofquercetinanditscombinationwithcisplatinonmalignantmesotheliomacellsinvitro
AT yanikkayademirelg investigationofeffectsofquercetinanditscombinationwithcisplatinonmalignantmesotheliomacellsinvitro

Ejemplares similares