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Seven Kinds of Intermediate Filament Networks in the Cytoplasm of Polarized Cells: Structure and Function
Intermediate filaments (IFs) are involved in many important physiological functions, such as the distribution of organelles, signal transduction, cell polarity and gene regulation. However, little information exists on the structure of the IF networks performing these functions. We have clarified th...
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Formato: | Texto |
Lenguaje: | English |
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Japan Society of Histochemistry and Cytochemistry
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2875862/ https://www.ncbi.nlm.nih.gov/pubmed/20514289 http://dx.doi.org/10.1267/ahc.10009 |
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author | Iwatsuki, Hirohiko Suda, Masumi |
author_facet | Iwatsuki, Hirohiko Suda, Masumi |
author_sort | Iwatsuki, Hirohiko |
collection | PubMed |
description | Intermediate filaments (IFs) are involved in many important physiological functions, such as the distribution of organelles, signal transduction, cell polarity and gene regulation. However, little information exists on the structure of the IF networks performing these functions. We have clarified the existence of seven kinds of IF networks in the cytoplasm of diverse polarized cells: an apex network just under the terminal web, a peripheral network lying just beneath the cell membrane, a granule-associated network surrounding a mass of secretory granules, a Golgi-associated network surrounding the Golgi apparatus, a radial network locating from the perinuclear region to the specific area of the cell membrane, a juxtanuclear network surrounding the nucleus, and an entire cytoplasmic network. In this review, we describe these seven kinds of IF networks and discuss their biological roles. |
format | Text |
id | pubmed-2875862 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Japan Society of Histochemistry and Cytochemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-28758622010-05-28 Seven Kinds of Intermediate Filament Networks in the Cytoplasm of Polarized Cells: Structure and Function Iwatsuki, Hirohiko Suda, Masumi Acta Histochem Cytochem Review Intermediate filaments (IFs) are involved in many important physiological functions, such as the distribution of organelles, signal transduction, cell polarity and gene regulation. However, little information exists on the structure of the IF networks performing these functions. We have clarified the existence of seven kinds of IF networks in the cytoplasm of diverse polarized cells: an apex network just under the terminal web, a peripheral network lying just beneath the cell membrane, a granule-associated network surrounding a mass of secretory granules, a Golgi-associated network surrounding the Golgi apparatus, a radial network locating from the perinuclear region to the specific area of the cell membrane, a juxtanuclear network surrounding the nucleus, and an entire cytoplasmic network. In this review, we describe these seven kinds of IF networks and discuss their biological roles. Japan Society of Histochemistry and Cytochemistry 2010-05-01 2010-04-21 /pmc/articles/PMC2875862/ /pubmed/20514289 http://dx.doi.org/10.1267/ahc.10009 Text en © 2010 The Japan Society of Histochemistry and Cytochemistry This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Iwatsuki, Hirohiko Suda, Masumi Seven Kinds of Intermediate Filament Networks in the Cytoplasm of Polarized Cells: Structure and Function |
title | Seven Kinds of Intermediate Filament Networks in the Cytoplasm of Polarized Cells: Structure and Function |
title_full | Seven Kinds of Intermediate Filament Networks in the Cytoplasm of Polarized Cells: Structure and Function |
title_fullStr | Seven Kinds of Intermediate Filament Networks in the Cytoplasm of Polarized Cells: Structure and Function |
title_full_unstemmed | Seven Kinds of Intermediate Filament Networks in the Cytoplasm of Polarized Cells: Structure and Function |
title_short | Seven Kinds of Intermediate Filament Networks in the Cytoplasm of Polarized Cells: Structure and Function |
title_sort | seven kinds of intermediate filament networks in the cytoplasm of polarized cells: structure and function |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2875862/ https://www.ncbi.nlm.nih.gov/pubmed/20514289 http://dx.doi.org/10.1267/ahc.10009 |
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