A novel EF-hand protein, CRACR2A, is a cytosolic Ca(2+) sensor that stabilizes CRAC channels in T cells

Orai1 and STIM1 are critical components of Ca(2+) release-activated Ca(2+) (CRAC) channels that mediate store-operated Ca(2+) entry (SOCE) in immune cells. While Orai1 and STIM1 co-cluster and physically interact to mediate SOCE, the cytoplasmic machinery modulating these functions remains poorly un...

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Detalles Bibliográficos
Autores principales: Srikanth, Sonal, Jung, Hea-Jin, Kim, Kyun-Do, Souda, Puneet, Whitelegge, Julian, Gwack, Yousang
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2875865/
https://www.ncbi.nlm.nih.gov/pubmed/20418871
http://dx.doi.org/10.1038/ncb2045

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2875865/
https://www.ncbi.nlm.nih.gov/pubmed/20418871
http://dx.doi.org/10.1038/ncb2045

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