Expression of (NES-)hTERT in Cancer Cells Delays Cell Cycle Progression and Increases Sensitivity to Genotoxic Stress

Telomerase is a reverse transcriptase associated with cellular immortality through telomere maintenance. This enzyme is activated in 90% of human cancers, and inhibitors of telomerase are currently in clinical trials to counteract tumor growth. Many aspects of telomerase biology have been investigat...

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Detalles Bibliográficos
Autores principales: Kovalenko, Olga A., Kaplunov, Jessica, Herbig, Utz, deToledo, Sonia, Azzam, Edouard I., Santos, Janine H.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2876026/
https://www.ncbi.nlm.nih.gov/pubmed/20520826
http://dx.doi.org/10.1371/journal.pone.0010812

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2876026/
https://www.ncbi.nlm.nih.gov/pubmed/20520826
http://dx.doi.org/10.1371/journal.pone.0010812

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