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Effect of Diashis, a polyherbal formulation, in streptozotocin-induced diabetic male albino rats

This study focuses on the effect of ‘Diashis’, a polyherbal formulation composed of eight medicinal plants for the management of streptozotocin (STZ)-induced diabetes in rats. As oxidative stress is one of the consequences of diabetes, the activities of hepatic antioxidant enzymes and metabolic enzy...

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Autores principales: Bera, Tushar K., De, Debasis, Chatterjee, Kausik, Ali, Kazi M., Ghosh, Debidas
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2876923/
https://www.ncbi.nlm.nih.gov/pubmed/20532093
http://dx.doi.org/10.4103/0974-7788.59939
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author Bera, Tushar K.
De, Debasis
Chatterjee, Kausik
Ali, Kazi M.
Ghosh, Debidas
author_facet Bera, Tushar K.
De, Debasis
Chatterjee, Kausik
Ali, Kazi M.
Ghosh, Debidas
author_sort Bera, Tushar K.
collection PubMed
description This study focuses on the effect of ‘Diashis’, a polyherbal formulation composed of eight medicinal plants for the management of streptozotocin (STZ)-induced diabetes in rats. As oxidative stress is one of the consequences of diabetes, the activities of hepatic antioxidant enzymes and metabolic enzymes were evaluated. Treatment with ‘Diashis’ in STZ-induced diabetic rats resulted in a significant (P < 0.01) recovery in the activities of hepatic hexokinase, glucose-6-phosphate dehydrogenase, and glucose-6-phosphatase along with correction in the levels of fasting blood glucose, glycated hemoglobin, and liver and skeletal muscle glycogen. The oxidative stress status in the liver was corrected by ‘Diashis’ which was highlighted by the recovery in the activities of catalase, peroxidase, and glutathione-S-transferase along with the correction in the quantity of thiobarbituric acid-reactive substances and conjugated diene. ‘Diashis’ was not found to have any metabolic toxicity. The antidiabetic effects of ‘Diashis’ were compared with those of the antidiabetic drug, ‘Glibenclamide’.
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spelling pubmed-28769232010-06-07 Effect of Diashis, a polyherbal formulation, in streptozotocin-induced diabetic male albino rats Bera, Tushar K. De, Debasis Chatterjee, Kausik Ali, Kazi M. Ghosh, Debidas Int J Ayurveda Res Original Article This study focuses on the effect of ‘Diashis’, a polyherbal formulation composed of eight medicinal plants for the management of streptozotocin (STZ)-induced diabetes in rats. As oxidative stress is one of the consequences of diabetes, the activities of hepatic antioxidant enzymes and metabolic enzymes were evaluated. Treatment with ‘Diashis’ in STZ-induced diabetic rats resulted in a significant (P < 0.01) recovery in the activities of hepatic hexokinase, glucose-6-phosphate dehydrogenase, and glucose-6-phosphatase along with correction in the levels of fasting blood glucose, glycated hemoglobin, and liver and skeletal muscle glycogen. The oxidative stress status in the liver was corrected by ‘Diashis’ which was highlighted by the recovery in the activities of catalase, peroxidase, and glutathione-S-transferase along with the correction in the quantity of thiobarbituric acid-reactive substances and conjugated diene. ‘Diashis’ was not found to have any metabolic toxicity. The antidiabetic effects of ‘Diashis’ were compared with those of the antidiabetic drug, ‘Glibenclamide’. Medknow Publications 2010 /pmc/articles/PMC2876923/ /pubmed/20532093 http://dx.doi.org/10.4103/0974-7788.59939 Text en © International Journal of Ayurveda Research http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Bera, Tushar K.
De, Debasis
Chatterjee, Kausik
Ali, Kazi M.
Ghosh, Debidas
Effect of Diashis, a polyherbal formulation, in streptozotocin-induced diabetic male albino rats
title Effect of Diashis, a polyherbal formulation, in streptozotocin-induced diabetic male albino rats
title_full Effect of Diashis, a polyherbal formulation, in streptozotocin-induced diabetic male albino rats
title_fullStr Effect of Diashis, a polyherbal formulation, in streptozotocin-induced diabetic male albino rats
title_full_unstemmed Effect of Diashis, a polyherbal formulation, in streptozotocin-induced diabetic male albino rats
title_short Effect of Diashis, a polyherbal formulation, in streptozotocin-induced diabetic male albino rats
title_sort effect of diashis, a polyherbal formulation, in streptozotocin-induced diabetic male albino rats
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2876923/
https://www.ncbi.nlm.nih.gov/pubmed/20532093
http://dx.doi.org/10.4103/0974-7788.59939
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