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Thrombospondin-1 null mice are resistant to hypoxia-induced pulmonary hypertension

BACKGROUND AND OBJECTIVE: Chronic hypoxia induces pulmonary hypertension in mice. Smooth muscle cell hyperplasia and medial thickening characterize the vasculature of these animals. Thrombospondin-1 null (TSP-1(-/-)) mice spontaneously develop pulmonary smooth muscle cell hyperplasia and medial thic...

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Detalles Bibliográficos
Autores principales:	Ochoa, Cristhiaan D, Yu, Lunyin, Al-Ansari, Essam, Hales, Charles A, Quinn, Deborah A
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2010
Materias:	Research article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2877040/ https://www.ncbi.nlm.nih.gov/pubmed/20441584 http://dx.doi.org/10.1186/1749-8090-5-32

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