High Glucose Suppresses Human Islet Insulin Biosynthesis by Inducing miR-133a Leading to Decreased Polypyrimidine Tract Binding Protein-Expression

BACKGROUND: Prolonged periods of high glucose exposure results in human islet dysfunction in vitro. The underlying mechanisms behind this effect of high glucose are, however, unknown. The polypyrimidine tract binding protein (PTB) is required for stabilization of insulin mRNA and the PTB mRNA 3′-UTR...

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Detalles Bibliográficos
Autores principales: Fred, Rikard G., Bang-Berthelsen, Claus H., Mandrup-Poulsen, Thomas, Grunnet, Lars G., Welsh, Nils
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2877094/
https://www.ncbi.nlm.nih.gov/pubmed/20520763
http://dx.doi.org/10.1371/journal.pone.0010843

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2877094/
https://www.ncbi.nlm.nih.gov/pubmed/20520763
http://dx.doi.org/10.1371/journal.pone.0010843

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