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Current trends in drug treatment of obsessive–compulsive disorder
This article aims to highlight current trends in the pharmacologic management of obsessive–compulsive disorder (OCD). A systematic search of the electronic database MEDLINE was conducted. The first case report of clomipramine efficacy in the management OCD more than 40 years ago gave new hope for th...
Autores principales: | , |
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Formato: | Texto |
Lenguaje: | English |
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Dove Medical Press
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2877605/ https://www.ncbi.nlm.nih.gov/pubmed/20520787 |
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author | Decloedt, Eric H Stein, Dan J |
author_facet | Decloedt, Eric H Stein, Dan J |
author_sort | Decloedt, Eric H |
collection | PubMed |
description | This article aims to highlight current trends in the pharmacologic management of obsessive–compulsive disorder (OCD). A systematic search of the electronic database MEDLINE was conducted. The first case report of clomipramine efficacy in the management OCD more than 40 years ago gave new hope for the treatment of this debilitating disorder. Selective serotonin reuptake inhibitors (SSRIs) proved to have a similar efficacy profile compared with clomipramine but had a superior tolerability profile. While many patients with OCD respond to SSRIs or clomipramine, the treatment of those with refractory OCD remains challenging. Different augmentation agents in treatment-resistant OCD have been explored, with antipsychotic agents having the largest supporting evidence base. Nevertheless, new pharmacologic treatment options are required and are under investigation. |
format | Text |
id | pubmed-2877605 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-28776052010-06-02 Current trends in drug treatment of obsessive–compulsive disorder Decloedt, Eric H Stein, Dan J Neuropsychiatr Dis Treat Review This article aims to highlight current trends in the pharmacologic management of obsessive–compulsive disorder (OCD). A systematic search of the electronic database MEDLINE was conducted. The first case report of clomipramine efficacy in the management OCD more than 40 years ago gave new hope for the treatment of this debilitating disorder. Selective serotonin reuptake inhibitors (SSRIs) proved to have a similar efficacy profile compared with clomipramine but had a superior tolerability profile. While many patients with OCD respond to SSRIs or clomipramine, the treatment of those with refractory OCD remains challenging. Different augmentation agents in treatment-resistant OCD have been explored, with antipsychotic agents having the largest supporting evidence base. Nevertheless, new pharmacologic treatment options are required and are under investigation. Dove Medical Press 2010-05-25 2010 /pmc/articles/PMC2877605/ /pubmed/20520787 Text en © 2010 Decloedt and Stein, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited. |
spellingShingle | Review Decloedt, Eric H Stein, Dan J Current trends in drug treatment of obsessive–compulsive disorder |
title | Current trends in drug treatment of obsessive–compulsive disorder |
title_full | Current trends in drug treatment of obsessive–compulsive disorder |
title_fullStr | Current trends in drug treatment of obsessive–compulsive disorder |
title_full_unstemmed | Current trends in drug treatment of obsessive–compulsive disorder |
title_short | Current trends in drug treatment of obsessive–compulsive disorder |
title_sort | current trends in drug treatment of obsessive–compulsive disorder |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2877605/ https://www.ncbi.nlm.nih.gov/pubmed/20520787 |
work_keys_str_mv | AT decloedterich currenttrendsindrugtreatmentofobsessivecompulsivedisorder AT steindanj currenttrendsindrugtreatmentofobsessivecompulsivedisorder |