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miR-22 Forms a Regulatory Loop in PTEN/AKT Pathway and Modulates Signaling Kinetics
BACKGROUND: The tumor suppressor PTEN (phosphatase and tensin homolog) is a lipid phosphatase that converts PIP3 into PIP2 and downregulates the kinase AKT and its proliferative and anti-apoptotic activities. The FoxO transcription factors are PTEN downstream effectors whose activity is negatively r...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2877705/ https://www.ncbi.nlm.nih.gov/pubmed/20523723 http://dx.doi.org/10.1371/journal.pone.0010859 |