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The Use of Orthologous Sequences to Predict the Impact of Amino Acid Substitutions on Protein Function

Computational predictions of the functional impact of genetic variation play a critical role in human genetics research. For nonsynonymous coding variants, most prediction algorithms make use of patterns of amino acid substitutions observed among homologous proteins at a given site. In particular, s...

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Detalles Bibliográficos
Autores principales:	Marini, Nicholas J., Thomas, Paul D., Rine, Jasper
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2877731/ https://www.ncbi.nlm.nih.gov/pubmed/20523748 http://dx.doi.org/10.1371/journal.pgen.1000968

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