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Hes1 expression is reduced in Tbx1 null cells and is required for the development of structures affected in 22q11 deletion syndrome
22q11 deletion syndrome (22q11DS) is characterised by aberrant development of the pharyngeal apparatus and the heart with haploinsufficiency of the transcription factor TBX1 being considered the major underlying cause of the disease. Tbx1 mutations in mouse phenocopy the disorder. In order to identi...
Autores principales: | van Bueren, Kelly Lammerts, Papangeli, Irinna, Rochais, Francesca, Pearce, Kerra, Roberts, Catherine, Calmont, Amelie, Szumska, Dorota, Kelly, Robert G., Bhattacharya, Shoumo, Scambler, Peter J. |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2877781/ https://www.ncbi.nlm.nih.gov/pubmed/20122914 http://dx.doi.org/10.1016/j.ydbio.2010.01.020 |
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