TNF-α and IL-1β increase Ca(2+) leak from the sarcoplasmic reticulum and susceptibility to arrhythmia in rat ventricular myocytes

Sepsis is associated with ventricular dysfunction and increased incidence of atrial and ventricular arrhythmia however the underlying pro-arrhythmic mechanisms are unknown. Serum levels of tumour necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) are elevated during sepsis and affect Ca(2+) regula...

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Detalles Bibliográficos
Autores principales: Duncan, David J., Yang, Zhaokang, Hopkins, Philip M., Steele, Derek S., Harrison, Simon M.
Formato: Texto
Lenguaje:English
Publicado: Elsevier 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2877880/
https://www.ncbi.nlm.nih.gov/pubmed/20227109
http://dx.doi.org/10.1016/j.ceca.2010.02.002

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