Cargando…

Developmental dyslexia in Chinese and English populations: dissociating the effect of dyslexia from language differences

Previous neuroimaging studies have suggested that developmental dyslexia has a different neural basis in Chinese and English populations because of known differences in the processing demands of the Chinese and English writing systems. Here, using functional magnetic resonance imaging, we provide th...

Descripción completa

Detalles Bibliográficos
Autores principales: Hu, Wei, Lee, Hwee Ling, Zhang, Qiang, Liu, Tao, Geng, Li Bo, Seghier, Mohamed L., Shakeshaft, Clare, Twomey, Tae, Green, David W., Yang, Yi Ming, Price, Cathy J.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2877905/
https://www.ncbi.nlm.nih.gov/pubmed/20488886
http://dx.doi.org/10.1093/brain/awq106
_version_ 1782181832616312832
author Hu, Wei
Lee, Hwee Ling
Zhang, Qiang
Liu, Tao
Geng, Li Bo
Seghier, Mohamed L.
Shakeshaft, Clare
Twomey, Tae
Green, David W.
Yang, Yi Ming
Price, Cathy J.
author_facet Hu, Wei
Lee, Hwee Ling
Zhang, Qiang
Liu, Tao
Geng, Li Bo
Seghier, Mohamed L.
Shakeshaft, Clare
Twomey, Tae
Green, David W.
Yang, Yi Ming
Price, Cathy J.
author_sort Hu, Wei
collection PubMed
description Previous neuroimaging studies have suggested that developmental dyslexia has a different neural basis in Chinese and English populations because of known differences in the processing demands of the Chinese and English writing systems. Here, using functional magnetic resonance imaging, we provide the first direct statistically based investigation into how the effect of dyslexia on brain activation is influenced by the Chinese and English writing systems. Brain activation for semantic decisions on written words was compared in English dyslexics, Chinese dyslexics, English normal readers and Chinese normal readers, while controlling for all other experimental parameters. By investigating the effects of dyslexia and language in one study, we show common activation in Chinese and English dyslexics despite different activation in Chinese versus English normal readers. The effect of dyslexia in both languages was observed as less than normal activation in the left angular gyrus and in left middle frontal, posterior temporal and occipitotemporal regions. Differences in Chinese and English normal reading were observed as increased activation for Chinese relative to English in the left inferior frontal sulcus; and increased activation for English relative to Chinese in the left posterior superior temporal sulcus. These cultural differences were not observed in dyslexics who activated both left inferior frontal sulcus and left posterior superior temporal sulcus, consistent with the use of culturally independent strategies when reading is less efficient. By dissociating the effect of dyslexia from differences in Chinese and English normal reading, our results reconcile brain activation results with a substantial body of behavioural studies showing commonalities in the cognitive manifestation of dyslexia in Chinese and English populations. They also demonstrate the influence of cognitive ability and learning environment on a common neural system for reading.
format Text
id pubmed-2877905
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-28779052010-05-28 Developmental dyslexia in Chinese and English populations: dissociating the effect of dyslexia from language differences Hu, Wei Lee, Hwee Ling Zhang, Qiang Liu, Tao Geng, Li Bo Seghier, Mohamed L. Shakeshaft, Clare Twomey, Tae Green, David W. Yang, Yi Ming Price, Cathy J. Brain Original Articles Previous neuroimaging studies have suggested that developmental dyslexia has a different neural basis in Chinese and English populations because of known differences in the processing demands of the Chinese and English writing systems. Here, using functional magnetic resonance imaging, we provide the first direct statistically based investigation into how the effect of dyslexia on brain activation is influenced by the Chinese and English writing systems. Brain activation for semantic decisions on written words was compared in English dyslexics, Chinese dyslexics, English normal readers and Chinese normal readers, while controlling for all other experimental parameters. By investigating the effects of dyslexia and language in one study, we show common activation in Chinese and English dyslexics despite different activation in Chinese versus English normal readers. The effect of dyslexia in both languages was observed as less than normal activation in the left angular gyrus and in left middle frontal, posterior temporal and occipitotemporal regions. Differences in Chinese and English normal reading were observed as increased activation for Chinese relative to English in the left inferior frontal sulcus; and increased activation for English relative to Chinese in the left posterior superior temporal sulcus. These cultural differences were not observed in dyslexics who activated both left inferior frontal sulcus and left posterior superior temporal sulcus, consistent with the use of culturally independent strategies when reading is less efficient. By dissociating the effect of dyslexia from differences in Chinese and English normal reading, our results reconcile brain activation results with a substantial body of behavioural studies showing commonalities in the cognitive manifestation of dyslexia in Chinese and English populations. They also demonstrate the influence of cognitive ability and learning environment on a common neural system for reading. Oxford University Press 2010-06 2010-05-20 /pmc/articles/PMC2877905/ /pubmed/20488886 http://dx.doi.org/10.1093/brain/awq106 Text en © The Author(s) 2010. Published by Oxford University Press on behalf of Brain. http://creativecommons.org/licenses/by-nc/2.5 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Hu, Wei
Lee, Hwee Ling
Zhang, Qiang
Liu, Tao
Geng, Li Bo
Seghier, Mohamed L.
Shakeshaft, Clare
Twomey, Tae
Green, David W.
Yang, Yi Ming
Price, Cathy J.
Developmental dyslexia in Chinese and English populations: dissociating the effect of dyslexia from language differences
title Developmental dyslexia in Chinese and English populations: dissociating the effect of dyslexia from language differences
title_full Developmental dyslexia in Chinese and English populations: dissociating the effect of dyslexia from language differences
title_fullStr Developmental dyslexia in Chinese and English populations: dissociating the effect of dyslexia from language differences
title_full_unstemmed Developmental dyslexia in Chinese and English populations: dissociating the effect of dyslexia from language differences
title_short Developmental dyslexia in Chinese and English populations: dissociating the effect of dyslexia from language differences
title_sort developmental dyslexia in chinese and english populations: dissociating the effect of dyslexia from language differences
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2877905/
https://www.ncbi.nlm.nih.gov/pubmed/20488886
http://dx.doi.org/10.1093/brain/awq106
work_keys_str_mv AT huwei developmentaldyslexiainchineseandenglishpopulationsdissociatingtheeffectofdyslexiafromlanguagedifferences
AT leehweeling developmentaldyslexiainchineseandenglishpopulationsdissociatingtheeffectofdyslexiafromlanguagedifferences
AT zhangqiang developmentaldyslexiainchineseandenglishpopulationsdissociatingtheeffectofdyslexiafromlanguagedifferences
AT liutao developmentaldyslexiainchineseandenglishpopulationsdissociatingtheeffectofdyslexiafromlanguagedifferences
AT genglibo developmentaldyslexiainchineseandenglishpopulationsdissociatingtheeffectofdyslexiafromlanguagedifferences
AT seghiermohamedl developmentaldyslexiainchineseandenglishpopulationsdissociatingtheeffectofdyslexiafromlanguagedifferences
AT shakeshaftclare developmentaldyslexiainchineseandenglishpopulationsdissociatingtheeffectofdyslexiafromlanguagedifferences
AT twomeytae developmentaldyslexiainchineseandenglishpopulationsdissociatingtheeffectofdyslexiafromlanguagedifferences
AT greendavidw developmentaldyslexiainchineseandenglishpopulationsdissociatingtheeffectofdyslexiafromlanguagedifferences
AT yangyiming developmentaldyslexiainchineseandenglishpopulationsdissociatingtheeffectofdyslexiafromlanguagedifferences
AT pricecathyj developmentaldyslexiainchineseandenglishpopulationsdissociatingtheeffectofdyslexiafromlanguagedifferences