Little Evidence for Genetic Susceptibility to Influenza A (H5N1) from Family Clustering Data

The apparent clustering of human cases of influenza A (H5N1) among blood relatives has been considered as evidence of genetic variation in susceptibility. We show that, by chance alone, a high proportion of clusters are expected to be limited to blood relatives when infection is a rare event.

Detalles Bibliográficos
Autores principales: Pitzer, Virginia E., Olsen, Sonja J., Bergstrom, Carl T., Dowell, Scott F., Lipsitch, Marc
Formato: Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2007
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2878232/
https://www.ncbi.nlm.nih.gov/pubmed/18214184
http://dx.doi.org/10.3201/eid1307.061538
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author Pitzer, Virginia E.
Olsen, Sonja J.
Bergstrom, Carl T.
Dowell, Scott F.
Lipsitch, Marc
author_facet Pitzer, Virginia E.
Olsen, Sonja J.
Bergstrom, Carl T.
Dowell, Scott F.
Lipsitch, Marc
author_sort Pitzer, Virginia E.
collection PubMed
description The apparent clustering of human cases of influenza A (H5N1) among blood relatives has been considered as evidence of genetic variation in susceptibility. We show that, by chance alone, a high proportion of clusters are expected to be limited to blood relatives when infection is a rare event.
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spelling pubmed-28782322010-06-03 Little Evidence for Genetic Susceptibility to Influenza A (H5N1) from Family Clustering Data Pitzer, Virginia E. Olsen, Sonja J. Bergstrom, Carl T. Dowell, Scott F. Lipsitch, Marc Emerg Infect Dis Dispatch The apparent clustering of human cases of influenza A (H5N1) among blood relatives has been considered as evidence of genetic variation in susceptibility. We show that, by chance alone, a high proportion of clusters are expected to be limited to blood relatives when infection is a rare event. Centers for Disease Control and Prevention 2007-07 /pmc/articles/PMC2878232/ /pubmed/18214184 http://dx.doi.org/10.3201/eid1307.061538 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Dispatch
Pitzer, Virginia E.
Olsen, Sonja J.
Bergstrom, Carl T.
Dowell, Scott F.
Lipsitch, Marc
Little Evidence for Genetic Susceptibility to Influenza A (H5N1) from Family Clustering Data
title Little Evidence for Genetic Susceptibility to Influenza A (H5N1) from Family Clustering Data
title_full Little Evidence for Genetic Susceptibility to Influenza A (H5N1) from Family Clustering Data
title_fullStr Little Evidence for Genetic Susceptibility to Influenza A (H5N1) from Family Clustering Data
title_full_unstemmed Little Evidence for Genetic Susceptibility to Influenza A (H5N1) from Family Clustering Data
title_short Little Evidence for Genetic Susceptibility to Influenza A (H5N1) from Family Clustering Data
title_sort little evidence for genetic susceptibility to influenza a (h5n1) from family clustering data
topic Dispatch
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2878232/
https://www.ncbi.nlm.nih.gov/pubmed/18214184
http://dx.doi.org/10.3201/eid1307.061538
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