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Antimicrobial Drugs and Community-acquired Methicillin-Resistant Staphylococcus aureus, United Kingdom
We report results of a case–control study of the association between receipt of antimicrobial agents and diagnosis of community-acquired methicillin-resistant Staphylococcus aureus (MRSA) in the United Kingdom. Eligible adults, selected from the General Practice Research Database, had no previous di...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Centers for Disease Control and Prevention
2007
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2878234/ https://www.ncbi.nlm.nih.gov/pubmed/18214170 http://dx.doi.org/10.3201/eid1307.061561 |
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author | Schneider-Lindner, Verena Delaney, J. A. Dial, Sandra Dascal, Andre Suissa, Samy |
author_facet | Schneider-Lindner, Verena Delaney, J. A. Dial, Sandra Dascal, Andre Suissa, Samy |
author_sort | Schneider-Lindner, Verena |
collection | PubMed |
description | We report results of a case–control study of the association between receipt of antimicrobial agents and diagnosis of community-acquired methicillin-resistant Staphylococcus aureus (MRSA) in the United Kingdom. Eligible adults, selected from the General Practice Research Database, had no previous diagnosis of MRSA, no hospitalization in the past 2 years, and >2 years of follow-up recorded in the database. For 2000–2004, we identified 1,981 MRSA case-patients and 19,779 matched control-patients. The odds ratios (ORs) and 95% confidence intervals (CIs) of MRSA diagnosis for patients who were prescribed 1, 2–3, or >4 antimicrobial drugs were 1.57 (CI 1.36–1.80), 2.46 (CI 2.15–2.83), and 6.24 (CI 5.43–7.17), respectively. Risk for community-acquired MRSA increased with number of antimicrobial drug prescriptions, appeared to vary according to antimicrobial drug classes prescribed the previous year, and was highest for quinolones (OR 3.37, CI 2.80–4.09) and macrolides (OR 2.50, CI 2.14–2.91). |
format | Text |
id | pubmed-2878234 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | Centers for Disease Control and Prevention |
record_format | MEDLINE/PubMed |
spelling | pubmed-28782342010-06-03 Antimicrobial Drugs and Community-acquired Methicillin-Resistant Staphylococcus aureus, United Kingdom Schneider-Lindner, Verena Delaney, J. A. Dial, Sandra Dascal, Andre Suissa, Samy Emerg Infect Dis Research We report results of a case–control study of the association between receipt of antimicrobial agents and diagnosis of community-acquired methicillin-resistant Staphylococcus aureus (MRSA) in the United Kingdom. Eligible adults, selected from the General Practice Research Database, had no previous diagnosis of MRSA, no hospitalization in the past 2 years, and >2 years of follow-up recorded in the database. For 2000–2004, we identified 1,981 MRSA case-patients and 19,779 matched control-patients. The odds ratios (ORs) and 95% confidence intervals (CIs) of MRSA diagnosis for patients who were prescribed 1, 2–3, or >4 antimicrobial drugs were 1.57 (CI 1.36–1.80), 2.46 (CI 2.15–2.83), and 6.24 (CI 5.43–7.17), respectively. Risk for community-acquired MRSA increased with number of antimicrobial drug prescriptions, appeared to vary according to antimicrobial drug classes prescribed the previous year, and was highest for quinolones (OR 3.37, CI 2.80–4.09) and macrolides (OR 2.50, CI 2.14–2.91). Centers for Disease Control and Prevention 2007-07 /pmc/articles/PMC2878234/ /pubmed/18214170 http://dx.doi.org/10.3201/eid1307.061561 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited. |
spellingShingle | Research Schneider-Lindner, Verena Delaney, J. A. Dial, Sandra Dascal, Andre Suissa, Samy Antimicrobial Drugs and Community-acquired Methicillin-Resistant Staphylococcus aureus, United Kingdom |
title | Antimicrobial Drugs and Community-acquired Methicillin-Resistant Staphylococcus aureus, United Kingdom |
title_full | Antimicrobial Drugs and Community-acquired Methicillin-Resistant Staphylococcus aureus, United Kingdom |
title_fullStr | Antimicrobial Drugs and Community-acquired Methicillin-Resistant Staphylococcus aureus, United Kingdom |
title_full_unstemmed | Antimicrobial Drugs and Community-acquired Methicillin-Resistant Staphylococcus aureus, United Kingdom |
title_short | Antimicrobial Drugs and Community-acquired Methicillin-Resistant Staphylococcus aureus, United Kingdom |
title_sort | antimicrobial drugs and community-acquired methicillin-resistant staphylococcus aureus, united kingdom |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2878234/ https://www.ncbi.nlm.nih.gov/pubmed/18214170 http://dx.doi.org/10.3201/eid1307.061561 |
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