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Protocol for a randomised controlled trial investigating the effectiveness of an online e-health application compared to attention placebo or sertraline in the treatment of generalised anxiety disorder
BACKGROUND: Generalised anxiety disorder (GAD) is a high prevalence, chronic psychiatric disorder which commonly presents early in the lifespan. Internet e-health applications have been found to be successful in reducing symptoms of anxiety and stress for post traumatic stress disorder (PTSD), panic...
Autores principales: | , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2878300/ https://www.ncbi.nlm.nih.gov/pubmed/20429947 http://dx.doi.org/10.1186/1745-6215-11-48 |
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author | Christensen, Helen Guastella, Adam J Mackinnon, Andrew J Griffiths, Kathleen M Eagleson, Claire Batterham, Philip J Kalia, Kanupriya Kenardy, Justin Bennett, Kylie Hickie, Ian B |
author_facet | Christensen, Helen Guastella, Adam J Mackinnon, Andrew J Griffiths, Kathleen M Eagleson, Claire Batterham, Philip J Kalia, Kanupriya Kenardy, Justin Bennett, Kylie Hickie, Ian B |
author_sort | Christensen, Helen |
collection | PubMed |
description | BACKGROUND: Generalised anxiety disorder (GAD) is a high prevalence, chronic psychiatric disorder which commonly presents early in the lifespan. Internet e-health applications have been found to be successful in reducing symptoms of anxiety and stress for post traumatic stress disorder (PTSD), panic disorder, social phobia and depression. However, to date, there is little evidence for the effectiveness of e-health applications in adult GAD. There are no studies which have directly compared e-health applications with recognised evidence-based medication. This study aims to determine the effectiveness of a web-based program for treating GAD relative to sertraline and attention placebo. METHODS/DESIGN: 120 community-dwelling participants, aged 18-30 years with a clinical diagnosis of GAD will be recruited from the Australian Electoral Roll. They will be randomly allocated to one of three conditions: (i) an online treatment program for GAD, E-couch (ii) pharmacological treatment with a selective serotonin re-uptake inhibitor (SSRI), sertraline (a fixed-flexible dose of 25-100 mg/day) or (iii) an attention control placebo, HealthWatch. The treatment program will be completed over a 10 week period with a 12 month follow-up. DISCUSSION: As of February 2010, there were no registered trials evaluating the effectiveness of an e-health application for GAD for young adults. Similarly to date, this will be the first trial to compare an e-health intervention with a pharmacological treatment. TRIAL REGISTRATION: Current Controlled Trials ISRCTN76298775 |
format | Text |
id | pubmed-2878300 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-28783002010-05-29 Protocol for a randomised controlled trial investigating the effectiveness of an online e-health application compared to attention placebo or sertraline in the treatment of generalised anxiety disorder Christensen, Helen Guastella, Adam J Mackinnon, Andrew J Griffiths, Kathleen M Eagleson, Claire Batterham, Philip J Kalia, Kanupriya Kenardy, Justin Bennett, Kylie Hickie, Ian B Trials Study protocol BACKGROUND: Generalised anxiety disorder (GAD) is a high prevalence, chronic psychiatric disorder which commonly presents early in the lifespan. Internet e-health applications have been found to be successful in reducing symptoms of anxiety and stress for post traumatic stress disorder (PTSD), panic disorder, social phobia and depression. However, to date, there is little evidence for the effectiveness of e-health applications in adult GAD. There are no studies which have directly compared e-health applications with recognised evidence-based medication. This study aims to determine the effectiveness of a web-based program for treating GAD relative to sertraline and attention placebo. METHODS/DESIGN: 120 community-dwelling participants, aged 18-30 years with a clinical diagnosis of GAD will be recruited from the Australian Electoral Roll. They will be randomly allocated to one of three conditions: (i) an online treatment program for GAD, E-couch (ii) pharmacological treatment with a selective serotonin re-uptake inhibitor (SSRI), sertraline (a fixed-flexible dose of 25-100 mg/day) or (iii) an attention control placebo, HealthWatch. The treatment program will be completed over a 10 week period with a 12 month follow-up. DISCUSSION: As of February 2010, there were no registered trials evaluating the effectiveness of an e-health application for GAD for young adults. Similarly to date, this will be the first trial to compare an e-health intervention with a pharmacological treatment. TRIAL REGISTRATION: Current Controlled Trials ISRCTN76298775 BioMed Central 2010-04-30 /pmc/articles/PMC2878300/ /pubmed/20429947 http://dx.doi.org/10.1186/1745-6215-11-48 Text en Copyright ©2010 Christensen et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Study protocol Christensen, Helen Guastella, Adam J Mackinnon, Andrew J Griffiths, Kathleen M Eagleson, Claire Batterham, Philip J Kalia, Kanupriya Kenardy, Justin Bennett, Kylie Hickie, Ian B Protocol for a randomised controlled trial investigating the effectiveness of an online e-health application compared to attention placebo or sertraline in the treatment of generalised anxiety disorder |
title | Protocol for a randomised controlled trial investigating the effectiveness of an online e-health application compared to attention placebo or sertraline in the treatment of generalised anxiety disorder |
title_full | Protocol for a randomised controlled trial investigating the effectiveness of an online e-health application compared to attention placebo or sertraline in the treatment of generalised anxiety disorder |
title_fullStr | Protocol for a randomised controlled trial investigating the effectiveness of an online e-health application compared to attention placebo or sertraline in the treatment of generalised anxiety disorder |
title_full_unstemmed | Protocol for a randomised controlled trial investigating the effectiveness of an online e-health application compared to attention placebo or sertraline in the treatment of generalised anxiety disorder |
title_short | Protocol for a randomised controlled trial investigating the effectiveness of an online e-health application compared to attention placebo or sertraline in the treatment of generalised anxiety disorder |
title_sort | protocol for a randomised controlled trial investigating the effectiveness of an online e-health application compared to attention placebo or sertraline in the treatment of generalised anxiety disorder |
topic | Study protocol |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2878300/ https://www.ncbi.nlm.nih.gov/pubmed/20429947 http://dx.doi.org/10.1186/1745-6215-11-48 |
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