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Exon Exchange Approach to Repair Duchenne Dystrophin Transcripts
BACKGROUND: Trans-splicing strategies for mRNA repair involve engineered transcripts designed to anneal target mRNAs in order to interfere with their natural splicing, giving rise to mRNA chimeras where endogenous mutated exons have been replaced by exogenous replacement sequences. A number of trans...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2878348/ https://www.ncbi.nlm.nih.gov/pubmed/20531943 http://dx.doi.org/10.1371/journal.pone.0010894 |