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Design of Group IIA Secreted/Synovial Phospholipase A(2) Inhibitors: An Oxadiazolone Derivative Suppresses Chondrocyte Prostaglandin E(2) Secretion

Group IIA secreted/synovial phospholipase A(2) (GIIAPLA(2)) is an enzyme involved in the synthesis of eicosanoids such as prostaglandin E(2) (PGE(2)), the main eicosanoid contributing to pain and inflammation in rheumatic diseases. We designed, by molecular modeling, 7 novel analogs of 3-{4-[5(indol...

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Detalles Bibliográficos
Autores principales:	Ombetta, Jean-Edouard, Thelier, Natacha, Dong, Chang Zhi, Plocki, Stéphanie, Tsagris, Lydia, Rannou, François, Massicot, France, Djimdé, Atimé, El-Hayek, Elissar, Shi, Yiming, Heymans, Françoise, Gresh, Nohad, Chauvet, Caroline
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2879362/ https://www.ncbi.nlm.nih.gov/pubmed/20531958 http://dx.doi.org/10.1371/journal.pone.0010914

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