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Evolutionary conservation of residues in vertebrate DNA polymerase N conferring low fidelity and bypass activity

POLN is a nuclear A-family DNA polymerase encoded in vertebrate genomes. POLN has unusual fidelity and DNA lesion bypass properties, including strong strand displacement activity, low fidelity favoring incorporation of T for template G and accurate translesion synthesis past a 5S-thymine glycol (5S-...

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Detalles Bibliográficos
Autores principales:	Takata, Kei-ichi, Arana, Mercedes E., Seki, Mineaki, Kunkel, Thomas A., Wood, Richard D.
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2010
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2879524/ https://www.ncbi.nlm.nih.gov/pubmed/20144948 http://dx.doi.org/10.1093/nar/gkq048

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