Cargando…

Leptin Inhibits the Proliferation of Vascular Smooth Muscle Cells Induced by Angiotensin II through Nitric Oxide-Dependent Mechanisms

Objective. This study was designed to investigate whether leptin modifies angiotensin (Ang) II-induced proliferation of aortic vascular smooth muscle cells (VSMCs) from 10-week-old male Wistar and spontaneously hypertensive rats (SHR), and the possible role of nitric oxide (NO). Methods. NO and NO s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rodríguez, Amaia, Gómez-Ambrosi, Javier, Catalán, Victoria, Fortuño, Ana, Frühbeck, Gema
Formato:	Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2879542/ https://www.ncbi.nlm.nih.gov/pubmed/20592755 http://dx.doi.org/10.1155/2010/105489

Ejemplares similares

Functional Relationship between Leptin and Nitric Oxide in Metabolism
por: Becerril, Sara, et al.
Publicado: (2019)

Deletion of Inducible Nitric-Oxide Synthase in Leptin-Deficient Mice Improves Brown Adipose Tissue Function
por: Becerril, Sara, et al.
Publicado: (2010)

Leptin Administration Downregulates the Increased Expression Levels of Genes Related to Oxidative Stress and Inflammation in the Skeletal Muscle of ob/ob Mice
por: Sáinz, Neira, et al.
Publicado: (2010)

Leptin Administration Favors Muscle Mass Accretion by Decreasing FoxO3a and Increasing PGC-1α in ob/ob Mice
por: Sáinz, Neira, et al.
Publicado: (2009)

Sex- and Age-Dependent Changes in the Adiponectin/Leptin Ratio in Experimental Diet-Induced Obesity in Mice
por: Becerril, Sara, et al.
Publicado: (2022)

Adiponectin-leptin Ratio is a Functional Biomarker of Adipose Tissue Inflammation
por: Frühbeck, Gema, et al.
Publicado: (2019)

iNOS Gene Ablation Prevents Liver Fibrosis in Leptin-Deficient ob/ob Mice
por: Becerril, Sara, et al.
Publicado: (2019)

Normalization of adiponectin concentrations by leptin replacement in ob/ob mice is accompanied by reductions in systemic oxidative stress and inflammation
por: Frühbeck, Gema, et al.
Publicado: (2017)

Involvement of the leptin-adiponectin axis in inflammation and oxidative stress in the metabolic syndrome
por: Frühbeck, Gema, et al.
Publicado: (2017)

Adipose tissue immunity and cancer
por: Catalán, Victoria, et al.
Publicado: (2013)

Leptin Reduces the Expression and Increases the Phosphorylation of the Negative Regulators of GLUT4 Traffic TBC1D1 and TBC1D4 in Muscle of ob/ob Mice
por: Sáinz, Neira, et al.
Publicado: (2012)

Resting Energy Expenditure Is Not Altered in Children and Adolescents with Obesity. Effect of Age and Gender and Association with Serum Leptin Levels
por: Zapata, J. Karina, et al.
Publicado: (2021)

Mechanisms Linking Excess Adiposity and Carcinogenesis Promotion
por: Pérez-Hernández, Ana I., et al.
Publicado: (2014)

Increase of the Adiponectin/Leptin Ratio in Patients with Obesity and Type 2 Diabetes after Roux-en-Y Gastric Bypass
por: Unamuno, Xabier, et al.
Publicado: (2019)

Relevance of body composition in phenotyping the obesities
por: Salmón-Gómez, Laura, et al.
Publicado: (2023)

Different Effects of Angiotensin II and Angiotensin-(1-7) on Vascular Smooth Muscle Cell Proliferation and Migration
por: Zhang, Feng, et al.
Publicado: (2010)

Leptin administration restores the altered adipose and hepatic expression of aquaglyceroporins improving the non-alcoholic fatty liver of ob/ob mice
por: Rodríguez, Amaia, et al.
Publicado: (2015)

Hexahydrocurcumin mitigates angiotensin II-induced proliferation, migration, and inflammation in vascular smooth muscle cells
por: Panthiya, Luckika, et al.
Publicado: (2023)

Functional angiotensin II receptors in cultured vascular smooth muscle cells
Publicado: (1982)

Kolaviron, Biflavonoid Complex from the Seed of Garcinia kola Attenuated Angiotensin II- and Lypopolysaccharide-induced Vascular Smooth Muscle Cell Proliferation and Nitric Oxide Production
por: Oyagbemi, Ademola Adetokunbo, et al.
Publicado: (2016)

Circulating GDF11 levels are decreased with age but are unchanged with obesity and type 2 diabetes
por: Añón-Hidalgo, Juan, et al.
Publicado: (2019)

FNDC4 and FNDC5 reduce SARS-CoV-2 entry points and spike glycoprotein S1-induced pyroptosis, apoptosis, and necroptosis in human adipocytes
por: Frühbeck, Gema, et al.
Publicado: (2021)

Acylated and desacyl ghrelin are associated with hepatic lipogenesis, β-oxidation and autophagy: role in NAFLD amelioration after sleeve gastrectomy in obese rats
por: Ezquerro, Silvia, et al.
Publicado: (2016)

Increased Levels of Interleukin-36 in Obesity and Type 2 Diabetes Fuel Adipose Tissue Inflammation by Inducing Its Own Expression and Release by Adipocytes and Macrophages
por: Frühbeck, Gema, et al.
Publicado: (2022)

Corrigendum: Increased levels of interleukin-36 in obesity and type 2 diabetes fuels adipose tissue inflammation by inducing its own expression and release by adipocytes and macrophages
por: Frühbeck, Gema, et al.
Publicado: (2023)

Protein Arginine Methyltransferase 2 Inhibits Angiotensin II-Induced Proliferation and Inflammation in Vascular Smooth Muscle Cells
por: Zeng, Si-yu, et al.
Publicado: (2018)

Osteopontin Deletion Prevents the Development of Obesity and Hepatic Steatosis via Impaired Adipose Tissue Matrix Remodeling and Reduced Inflammation and Fibrosis in Adipose Tissue and Liver in Mice
por: Lancha, Andoni, et al.
Publicado: (2014)

BMI-based obesity classification misses children and adolescents with raised cardiometabolic risk due to increased adiposity
por: Zapata, J. Karina, et al.
Publicado: (2023)

Angiotensin II-Regulated Autophagy Is Required for Vascular Smooth Muscle Cell Hypertrophy
por: Mondaca-Ruff, David, et al.
Publicado: (2019)

Adiponectin Attenuates Angiotensin II-Induced Vascular Smooth Muscle Cell Remodeling through Nitric Oxide and the RhoA/ROCK Pathway
por: Nour-Eldine, Wared, et al.
Publicado: (2016)

Genistein suppresses leptin‐induced proliferation and migration of vascular smooth muscle cells and neointima formation
por: Tsai, Yung‐Chieh, et al.
Publicado: (2016)

Dermatopontin, A Novel Adipokine Promoting Adipose Tissue Extracellular Matrix Remodelling and Inflammation in Obesity †
por: Unamuno, Xabier, et al.
Publicado: (2020)

Serum Levels of IL-1 RA Increase with Obesity and Type 2 Diabetes in Relation to Adipose Tissue Dysfunction and are Reduced After Bariatric Surgery in Parallel to Adiposity
por: Frühbeck, Gema, et al.
Publicado: (2022)

Angiotensin II, Hypercholesterolemia, and Vascular Smooth Muscle Cells: A Perfect Trio for Vascular Pathology
por: St. Paul, Amanda, et al.
Publicado: (2020)

Caloric Restriction Prevents Metabolic Dysfunction and the Changes in Hypothalamic Neuropeptides Associated with Obesity Independently of Dietary Fat Content in Rats
por: Martín, Marina, et al.
Publicado: (2021)

Time to Consider the “Exposome Hypothesis” in the Development of the Obesity Pandemic
por: Catalán, Victoria, et al.
Publicado: (2022)

Rosiglitzone Suppresses Angiotensin II-Induced Production of KLF5 and Cell Proliferation in Rat Vascular Smooth Muscle Cells
por: Gao, Dengfeng, et al.
Publicado: (2015)

The GTPase ARF6 Controls ROS Production to Mediate Angiotensin II-Induced Vascular Smooth Muscle Cell Proliferation
por: Bourmoum, Mohamed, et al.
Publicado: (2016)

The effect of adrenomedullin and proadrenomedullin N-terminal 20 peptide on angiotensin II induced vascular smooth muscle cell proliferation
por: Ma, Jian, et al.
Publicado: (2016)

Dermatopontin Influences the Development of Obesity-Associated Colon Cancer by Changes in the Expression of Extracellular Matrix Proteins
por: Catalán, Victoria, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_a1tu34o0to6kslnbk04mu9800g