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Transformation of a Cutaneous Follicle Center Lymphoma to a Diffuse Large B-Cell Lymphoma—An Unusual Presentation

Primary cutaneous follicle center lymphoma (PCFCL) is characterized by a proliferation of follicle center cells in the skin. A definitive diagnosis is frequently delayed because of difficulties in interpretation of the histopathologic findings. It has an excellent prognosis with a 5-year survival ov...

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Autores principales: Dias Coelho, J., Diamantino, F., Costa, I., Farinha, P., Gameiro, P., Sebastião, M., Baptista, J.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2879550/
https://www.ncbi.nlm.nih.gov/pubmed/20589072
http://dx.doi.org/10.1155/2010/296523
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author Dias Coelho, J.
Diamantino, F.
Costa, I.
Farinha, P.
Gameiro, P.
Sebastião, M.
Baptista, J.
author_facet Dias Coelho, J.
Diamantino, F.
Costa, I.
Farinha, P.
Gameiro, P.
Sebastião, M.
Baptista, J.
author_sort Dias Coelho, J.
collection PubMed
description Primary cutaneous follicle center lymphoma (PCFCL) is characterized by a proliferation of follicle center cells in the skin. A definitive diagnosis is frequently delayed because of difficulties in interpretation of the histopathologic findings. It has an excellent prognosis with a 5-year survival over 95% and its risk of transformation has not been established. We describe a case report of man with a gastric diffuse large B-cell lymphoma (DLBCL) referred to our clinic because of nodules in the back that had gradually developed over a period of 10 years. A biopsy performed 3 years before was interpreted as reactive follicular hyperplasia. A new skin biopsy revealed a diffuse large B-cell lymphoma and immunoglobulin heavy chain gene rearrangements from the initial skin biopsy (PCBCL) and the DLBCL gastric biopsy were studied by polymerase chain reaction and an identical clonal rearrangement was detected which was highly suggestive of a transformation lymphoma.
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spelling pubmed-28795502010-06-29 Transformation of a Cutaneous Follicle Center Lymphoma to a Diffuse Large B-Cell Lymphoma—An Unusual Presentation Dias Coelho, J. Diamantino, F. Costa, I. Farinha, P. Gameiro, P. Sebastião, M. Baptista, J. Case Rep Med Case Report Primary cutaneous follicle center lymphoma (PCFCL) is characterized by a proliferation of follicle center cells in the skin. A definitive diagnosis is frequently delayed because of difficulties in interpretation of the histopathologic findings. It has an excellent prognosis with a 5-year survival over 95% and its risk of transformation has not been established. We describe a case report of man with a gastric diffuse large B-cell lymphoma (DLBCL) referred to our clinic because of nodules in the back that had gradually developed over a period of 10 years. A biopsy performed 3 years before was interpreted as reactive follicular hyperplasia. A new skin biopsy revealed a diffuse large B-cell lymphoma and immunoglobulin heavy chain gene rearrangements from the initial skin biopsy (PCBCL) and the DLBCL gastric biopsy were studied by polymerase chain reaction and an identical clonal rearrangement was detected which was highly suggestive of a transformation lymphoma. Hindawi Publishing Corporation 2010 2010-05-31 /pmc/articles/PMC2879550/ /pubmed/20589072 http://dx.doi.org/10.1155/2010/296523 Text en Copyright © 2010 J. Dias Coelho et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Dias Coelho, J.
Diamantino, F.
Costa, I.
Farinha, P.
Gameiro, P.
Sebastião, M.
Baptista, J.
Transformation of a Cutaneous Follicle Center Lymphoma to a Diffuse Large B-Cell Lymphoma—An Unusual Presentation
title Transformation of a Cutaneous Follicle Center Lymphoma to a Diffuse Large B-Cell Lymphoma—An Unusual Presentation
title_full Transformation of a Cutaneous Follicle Center Lymphoma to a Diffuse Large B-Cell Lymphoma—An Unusual Presentation
title_fullStr Transformation of a Cutaneous Follicle Center Lymphoma to a Diffuse Large B-Cell Lymphoma—An Unusual Presentation
title_full_unstemmed Transformation of a Cutaneous Follicle Center Lymphoma to a Diffuse Large B-Cell Lymphoma—An Unusual Presentation
title_short Transformation of a Cutaneous Follicle Center Lymphoma to a Diffuse Large B-Cell Lymphoma—An Unusual Presentation
title_sort transformation of a cutaneous follicle center lymphoma to a diffuse large b-cell lymphoma—an unusual presentation
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2879550/
https://www.ncbi.nlm.nih.gov/pubmed/20589072
http://dx.doi.org/10.1155/2010/296523
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