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Prediction of breast cancer sensitivity to neoadjuvant chemotherapy based on status of DNA damage repair proteins
INTRODUCTION: Various agents used in breast cancer chemotherapy provoke DNA double-strand breaks (DSBs). DSB repair competence determines the sensitivity of cells to these agents whereby aberrations in the repair machinery leads to apoptosis. Proteins required for this pathway can be detected as nuc...
Autores principales: | , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2879561/ https://www.ncbi.nlm.nih.gov/pubmed/20205718 http://dx.doi.org/10.1186/bcr2486 |