Increased plasma membrane cholesterol in cystic fibrosis cells correlates with CFTR genotype and depends on de novo cholesterol synthesis

BACKGROUND: Previous observations demonstrate that Cftr-null cells and tissues exhibit alterations in cholesterol processing including perinuclear cholesterol accumulation, increased de novo synthesis, and an increase in plasma membrane cholesterol accessibility compared to wild type controls. The h...

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Detalles Bibliográficos
Autores principales: Fang, Danjun, West, Richard H, Manson, Mary E, Ruddy, Jennifer, Jiang, Dechen, Previs, Stephen F, Sonawane, Nitin D, Burgess, James D, Kelley, Thomas J
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2880018/
https://www.ncbi.nlm.nih.gov/pubmed/20487541
http://dx.doi.org/10.1186/1465-9921-11-61

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