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High-dose chemotherapy and autologous stem cell rescue for atypical teratoid/rhabdoid tumor of the central nervous system
Atypical Teratoid/Rhabdoid tumors (AT/RT) of the central nervous system are rare but aggressive tumors of childhood. Median survival with surgery and standard chemotherapy is less than 12 months. In an attempt to improve outcome, patients were treated with aggressive surgical resection and multi-age...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Springer US
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2880232/ https://www.ncbi.nlm.nih.gov/pubmed/19936623 http://dx.doi.org/10.1007/s11060-009-0071-6 |
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author | Nicolaides, Theodore Tihan, Tarik Horn, Biljana Biegel, Jaclyn Prados, Michael Banerjee, Anuradha |
author_facet | Nicolaides, Theodore Tihan, Tarik Horn, Biljana Biegel, Jaclyn Prados, Michael Banerjee, Anuradha |
author_sort | Nicolaides, Theodore |
collection | PubMed |
description | Atypical Teratoid/Rhabdoid tumors (AT/RT) of the central nervous system are rare but aggressive tumors of childhood. Median survival with surgery and standard chemotherapy is less than 12 months. In an attempt to improve outcome, patients were treated with aggressive surgical resection and multi-agent chemotherapy, followed by high dose chemotherapy with autologous stem cell rescue. Nine consecutive children (median age 21 months) were diagnosed with AT/RT at the University of California San Francisco Childrens Hospital from 1997 to 2007 and treated with this aggressive approach. Diagnosis was confirmed using molecular markers. There are two long-term survivors (78 and 98 months from diagnosis). One additional patient is alive with disease. Three patients died of disease during therapy. Three patients died of disease after therapy was complete. There were no toxic deaths. Two of nine patients treated for AT/RT at our institution with high dose chemotherapy and autologous bone marrow transplant are long-term survivors, suggesting that a subset of patients can be cured with this approach. |
format | Text |
id | pubmed-2880232 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-28802322010-06-07 High-dose chemotherapy and autologous stem cell rescue for atypical teratoid/rhabdoid tumor of the central nervous system Nicolaides, Theodore Tihan, Tarik Horn, Biljana Biegel, Jaclyn Prados, Michael Banerjee, Anuradha J Neurooncol Clinical Study - Patient Study Atypical Teratoid/Rhabdoid tumors (AT/RT) of the central nervous system are rare but aggressive tumors of childhood. Median survival with surgery and standard chemotherapy is less than 12 months. In an attempt to improve outcome, patients were treated with aggressive surgical resection and multi-agent chemotherapy, followed by high dose chemotherapy with autologous stem cell rescue. Nine consecutive children (median age 21 months) were diagnosed with AT/RT at the University of California San Francisco Childrens Hospital from 1997 to 2007 and treated with this aggressive approach. Diagnosis was confirmed using molecular markers. There are two long-term survivors (78 and 98 months from diagnosis). One additional patient is alive with disease. Three patients died of disease during therapy. Three patients died of disease after therapy was complete. There were no toxic deaths. Two of nine patients treated for AT/RT at our institution with high dose chemotherapy and autologous bone marrow transplant are long-term survivors, suggesting that a subset of patients can be cured with this approach. Springer US 2009-11-22 2010 /pmc/articles/PMC2880232/ /pubmed/19936623 http://dx.doi.org/10.1007/s11060-009-0071-6 Text en © The Author(s) 2009 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. |
spellingShingle | Clinical Study - Patient Study Nicolaides, Theodore Tihan, Tarik Horn, Biljana Biegel, Jaclyn Prados, Michael Banerjee, Anuradha High-dose chemotherapy and autologous stem cell rescue for atypical teratoid/rhabdoid tumor of the central nervous system |
title | High-dose chemotherapy and autologous stem cell rescue for atypical teratoid/rhabdoid tumor of the central nervous system |
title_full | High-dose chemotherapy and autologous stem cell rescue for atypical teratoid/rhabdoid tumor of the central nervous system |
title_fullStr | High-dose chemotherapy and autologous stem cell rescue for atypical teratoid/rhabdoid tumor of the central nervous system |
title_full_unstemmed | High-dose chemotherapy and autologous stem cell rescue for atypical teratoid/rhabdoid tumor of the central nervous system |
title_short | High-dose chemotherapy and autologous stem cell rescue for atypical teratoid/rhabdoid tumor of the central nervous system |
title_sort | high-dose chemotherapy and autologous stem cell rescue for atypical teratoid/rhabdoid tumor of the central nervous system |
topic | Clinical Study - Patient Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2880232/ https://www.ncbi.nlm.nih.gov/pubmed/19936623 http://dx.doi.org/10.1007/s11060-009-0071-6 |
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