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Hsk1- and SCF(Pof3)-Dependent Proteolysis of S. pombe Ams2 Ensures Histone Homeostasis and Centromere Function
Schizosaccharomyces pombe GATA factor Ams2 is responsible for cell cycle-dependent transcriptional activation of all the core histone genes peaking at G1/S phase. Intriguingly, its own protein level also fluctuates concurrently. Here, we show that Ams2 is ubiquitylated and degraded through the SCF (...
| Autores principales: | , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Cell Press
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2880248/ https://www.ncbi.nlm.nih.gov/pubmed/20230746 http://dx.doi.org/10.1016/j.devcel.2009.12.024 |