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Location, location, location…site-specific GPCR phosphorylation offers a mechanism for cell-type-specific signalling
It is now established that most of the ∼800 G-protein-coupled receptors (GPCRs) are regulated by phosphorylation in a process that results in the recruitment of arrestins, leading to receptor desensitization and the activation of arrestin-dependent processes. This generalized view of GPCR regulation...
Autores principales: | , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Published By Elsevier In Association With The International Union Of Pharmacology
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2880250/ https://www.ncbi.nlm.nih.gov/pubmed/18606460 http://dx.doi.org/10.1016/j.tips.2008.05.006 |
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author | Tobin, Andrew B. Butcher, Adrian J. Kong, Kok Choi |
author_facet | Tobin, Andrew B. Butcher, Adrian J. Kong, Kok Choi |
author_sort | Tobin, Andrew B. |
collection | PubMed |
description | It is now established that most of the ∼800 G-protein-coupled receptors (GPCRs) are regulated by phosphorylation in a process that results in the recruitment of arrestins, leading to receptor desensitization and the activation of arrestin-dependent processes. This generalized view of GPCR regulation, however, does not provide an adequate mechanism for the control of tissue-specific GPCR signalling. Here, we review the evidence that GPCR phosphorylation is, in fact, a flexible and dynamic regulatory process in which GPCRs are phosphorylated in a unique manner that is associated with the cell type in which the receptor is expressed. In this scenario, phosphorylation offers a mechanism of regulating the signalling outcome of GPCRs that can be tailored to meet a specific physiological role. |
format | Text |
id | pubmed-2880250 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | Published By Elsevier In Association With The International Union Of Pharmacology |
record_format | MEDLINE/PubMed |
spelling | pubmed-28802502010-07-09 Location, location, location…site-specific GPCR phosphorylation offers a mechanism for cell-type-specific signalling Tobin, Andrew B. Butcher, Adrian J. Kong, Kok Choi Trends Pharmacol Sci Review It is now established that most of the ∼800 G-protein-coupled receptors (GPCRs) are regulated by phosphorylation in a process that results in the recruitment of arrestins, leading to receptor desensitization and the activation of arrestin-dependent processes. This generalized view of GPCR regulation, however, does not provide an adequate mechanism for the control of tissue-specific GPCR signalling. Here, we review the evidence that GPCR phosphorylation is, in fact, a flexible and dynamic regulatory process in which GPCRs are phosphorylated in a unique manner that is associated with the cell type in which the receptor is expressed. In this scenario, phosphorylation offers a mechanism of regulating the signalling outcome of GPCRs that can be tailored to meet a specific physiological role. Published By Elsevier In Association With The International Union Of Pharmacology 2008-08 /pmc/articles/PMC2880250/ /pubmed/18606460 http://dx.doi.org/10.1016/j.tips.2008.05.006 Text en © 2008 Elsevier Ltd. https://creativecommons.org/licenses/by/3.0/ Open Access under CC BY 3.0 (https://creativecommons.org/licenses/by/3.0/) license |
spellingShingle | Review Tobin, Andrew B. Butcher, Adrian J. Kong, Kok Choi Location, location, location…site-specific GPCR phosphorylation offers a mechanism for cell-type-specific signalling |
title | Location, location, location…site-specific GPCR phosphorylation offers a mechanism for cell-type-specific signalling |
title_full | Location, location, location…site-specific GPCR phosphorylation offers a mechanism for cell-type-specific signalling |
title_fullStr | Location, location, location…site-specific GPCR phosphorylation offers a mechanism for cell-type-specific signalling |
title_full_unstemmed | Location, location, location…site-specific GPCR phosphorylation offers a mechanism for cell-type-specific signalling |
title_short | Location, location, location…site-specific GPCR phosphorylation offers a mechanism for cell-type-specific signalling |
title_sort | location, location, location…site-specific gpcr phosphorylation offers a mechanism for cell-type-specific signalling |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2880250/ https://www.ncbi.nlm.nih.gov/pubmed/18606460 http://dx.doi.org/10.1016/j.tips.2008.05.006 |
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