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Steady State Detection of Chemical Reaction Networks Using a Simplified Analytical Method

Chemical reaction networks (CRNs) are susceptible to mathematical modelling. The dynamic behavior of CRNs can be investigated by solving the polynomial equations derived from its structure. However, simple CRN give rise to non-linear polynomials that are difficult to resolve. Here we propose a proce...

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Detalles Bibliográficos
Autores principales: Martínez-Forero, Ivan, Peláez-López, Antonio, Villoslada, Pablo
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2880584/
https://www.ncbi.nlm.nih.gov/pubmed/20532219
http://dx.doi.org/10.1371/journal.pone.0010823
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author Martínez-Forero, Ivan
Peláez-López, Antonio
Villoslada, Pablo
author_facet Martínez-Forero, Ivan
Peláez-López, Antonio
Villoslada, Pablo
author_sort Martínez-Forero, Ivan
collection PubMed
description Chemical reaction networks (CRNs) are susceptible to mathematical modelling. The dynamic behavior of CRNs can be investigated by solving the polynomial equations derived from its structure. However, simple CRN give rise to non-linear polynomials that are difficult to resolve. Here we propose a procedure to locate the steady states of CRNs from a formula derived through algebraic geometry methods. We have applied this procedure to define the steady states of a classic CRN that exhibits instability, and to a model of programmed cell death.
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spelling pubmed-28805842010-06-07 Steady State Detection of Chemical Reaction Networks Using a Simplified Analytical Method Martínez-Forero, Ivan Peláez-López, Antonio Villoslada, Pablo PLoS One Research Article Chemical reaction networks (CRNs) are susceptible to mathematical modelling. The dynamic behavior of CRNs can be investigated by solving the polynomial equations derived from its structure. However, simple CRN give rise to non-linear polynomials that are difficult to resolve. Here we propose a procedure to locate the steady states of CRNs from a formula derived through algebraic geometry methods. We have applied this procedure to define the steady states of a classic CRN that exhibits instability, and to a model of programmed cell death. Public Library of Science 2010-06-03 /pmc/articles/PMC2880584/ /pubmed/20532219 http://dx.doi.org/10.1371/journal.pone.0010823 Text en Martínez-Foreroet al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Martínez-Forero, Ivan
Peláez-López, Antonio
Villoslada, Pablo
Steady State Detection of Chemical Reaction Networks Using a Simplified Analytical Method
title Steady State Detection of Chemical Reaction Networks Using a Simplified Analytical Method
title_full Steady State Detection of Chemical Reaction Networks Using a Simplified Analytical Method
title_fullStr Steady State Detection of Chemical Reaction Networks Using a Simplified Analytical Method
title_full_unstemmed Steady State Detection of Chemical Reaction Networks Using a Simplified Analytical Method
title_short Steady State Detection of Chemical Reaction Networks Using a Simplified Analytical Method
title_sort steady state detection of chemical reaction networks using a simplified analytical method
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2880584/
https://www.ncbi.nlm.nih.gov/pubmed/20532219
http://dx.doi.org/10.1371/journal.pone.0010823
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