Cargando…

Optimality of Mutation and Selection in Germinal Centers

The population dynamics theory of B cells in a typical germinal center could play an important role in revealing how affinity maturation is achieved. However, the existing models encountered some conflicts with experiments. To resolve these conflicts, we present a coarse-grained model to calculate t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Jingshan, Shakhnovich, Eugene I.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2880589/ https://www.ncbi.nlm.nih.gov/pubmed/20532164 http://dx.doi.org/10.1371/journal.pcbi.1000800

Ejemplares similares

Interplay between Pleiotropy and Secondary Selection Determines Rise and Fall of Mutators in Stress Response
por: Heo, Muyoung, et al.
Publicado: (2010)

Constraints imposed by non-functional protein–protein interactions on gene expression and proteome size
por: Zhang, Jingshan, et al.
Publicado: (2008)

Mutation Induced Extinction in Finite Populations: Lethal Mutagenesis and Lethal Isolation
por: Wylie, C. Scott, et al.
Publicado: (2012)

Defects in Germinal Center Selection in SLE
por: Woods, Megan, et al.
Publicado: (2015)

Evidence of evolutionary selection for cotranslational folding
por: Jacobs, William M., et al.
Publicado: (2017)

Positive Selection in the Light Zone of Germinal Centers
por: Nakagawa, Rinako, et al.
Publicado: (2021)

Adaptation to mutational inactivation of an essential gene converges to an accessible suboptimal fitness peak
por: Rodrigues, João V, et al.
Publicado: (2019)

TLR7 Influences Germinal Center Selection in Murine SLE
por: Boneparth, Alexis, et al.
Publicado: (2015)

Dynamic Regulation of Tfh Selection During the Germinal Center Reaction
por: Merkenschlager, Julia, et al.
Publicado: (2021)

Contribution of Selection for Protein Folding Stability in Shaping the Patterns of Polymorphisms in Coding Regions
por: Serohijos, Adrian W.R., et al.
Publicado: (2014)

Tunable dynamics of B cell selection in gut germinal centers
por: Nowosad, Carla R., et al.
Publicado: (2020)

Low-level Hypermutation in T Cell–independent Germinal Centers Compared with High Mutation Rates Associated with T Cell–dependent Germinal Centers
por: Toellner, Kai-Michael, et al.
Publicado: (2002)

Positively Selected Sites in Cetacean Myoglobins Contribute to Protein Stability
por: Dasmeh, Pouria, et al.
Publicado: (2013)

The Influence of Selection for Protein Stability on dN/dS Estimations
por: Dasmeh, Pouria, et al.
Publicado: (2014)

Affinity Selection in Germinal Centers: Cautionary Tales and New Opportunities
por: Faro, Jose, et al.
Publicado: (2021)

Bayesian optimization for seed germination
por: Nikitin, Artyom, et al.
Publicado: (2019)

c-MYC is required for germinal center selection and cyclic re-entry
por: Dominguez-Sola, David, et al.
Publicado: (2012)

Modulation of Igβ is essential for the B cell selection in germinal center
por: Todo, Kagefumi, et al.
Publicado: (2015)

Assessing the Effect of Loop Mutations in the Folding Space of β(2)-Microglobulin with Molecular Dynamics Simulations
por: Estácio, Sílvia G., et al.
Publicado: (2013)

A mechanism of T cell dependent selection of antigen engaged Germinal Center B cells
por: Krishna, Vinod, et al.
Publicado: (2018)

Components Essential for the Generation of Germinal Centers
por: Rizzo, L. V., et al.
Publicado: (1998)

Germinal Centers without T Cells
por: de Vinuesa, Carola García, et al.
Publicado: (2000)

Metabolic response to point mutations reveals principles of modulation of in vivo enzyme activity and phenotype
por: Bhattacharyya, Sanchari, et al.
Publicado: (2021)

A First-Principles Model of Early Evolution: Emergence of Gene Families, Species, and Preferred Protein Folds
por: Zeldovich, Konstantin B, et al.
Publicado: (2007)

Catalysis of Protein Folding by Chaperones Accelerates Evolutionary Dynamics in Adapting Cell Populations
por: Çetinbaş, Murat, et al.
Publicado: (2013)

The Dynamics of Germinal Centre Selection as Measured by Graph-Theoretical Analysis of Mutational Lineage Trees
por: Dunn-Walters, Deborah K., et al.
Publicado: (2002)

Mutation of chromatin modifiers; an emerging hallmark of germinal center B-cell lymphomas
por: Lunning, M A, et al.
Publicado: (2015)

An approach to measuring germinal mutations in the mouse.
por: Valcovic, L R, et al.
Publicado: (1973)

Germinal centers are free for all
por: Bashyam, Hema
Publicado: (2007)

Synaptic Interactions in Germinal Centers
por: Papa, Ilenia, et al.
Publicado: (2018)

Regulation of the Germinal Center Response
por: Stebegg, Marisa, et al.
Publicado: (2018)

Cytokines in the Germinal Center Niche
por: Jandl, Christoph, et al.
Publicado: (2016)

Germinal Center Founder Cells Display Propensity for Apoptosis before Onset of Somatic Mutation
por: Lebecque, Serge, et al.
Publicado: (1997)

Erratum: Modulation of Igβ is essential for the B cell selection in germinal center
por: Todo, Kagefumi, et al.
Publicado: (2015)

Mutational mechanisms shaping the coding and noncoding genome of germinal center derived B-cell lymphomas
por: Hübschmann, Daniel, et al.
Publicado: (2021)

Negative selection of human germinal center B cells by prolonged BCR cross-linking
Publicado: (1996)

The RNA binding protein PTBP1 is necessary for B cell selection in germinal centers
por: Monzón-Casanova, Elisa, et al.
Publicado: (2018)

Germinal center entry not selection of B cells is controlled by peptide-MHCII complex density
por: Yeh, Chen-Hao, et al.
Publicado: (2018)

STIM-mediated calcium influx regulates maintenance and selection of germinal center B cells
por: Yada, Yutaro, et al.
Publicado: (2023)

Antibody Mediated Intercommunication of Germinal Centers
por: Arulraj, Theinmozhi, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_pj6an7mbc50c7jbnv6vtldpk2u