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Optimality of Mutation and Selection in Germinal Centers

The population dynamics theory of B cells in a typical germinal center could play an important role in revealing how affinity maturation is achieved. However, the existing models encountered some conflicts with experiments. To resolve these conflicts, we present a coarse-grained model to calculate t...

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Detalles Bibliográficos
Autores principales:	Zhang, Jingshan, Shakhnovich, Eugene I.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2880589/ https://www.ncbi.nlm.nih.gov/pubmed/20532164 http://dx.doi.org/10.1371/journal.pcbi.1000800

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