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Lowering β-Amyloid Levels Rescues Learning and Memory in a Down Syndrome Mouse Model

β-amyloid levels are elevated in Down syndrome (DS) patients throughout life and are believed to cause Alzheimer's disease (AD) in adult members of this population. However, it is not known if β-amyloid contributes to intellectual disability in younger individuals. We used a γ-secretase inhibit...

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Detalles Bibliográficos
Autores principales:	Netzer, William J., Powell, Craig, Nong, Yi, Blundell, Jacqueline, Wong, Lili, Duff, Karen, Flajolet, Marc, Greengard, Paul
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2880593/ https://www.ncbi.nlm.nih.gov/pubmed/20532168 http://dx.doi.org/10.1371/journal.pone.0010943

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