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Structural and Dynamical Effects Induced by the Anticancer Drug Topotecan on the Human Topoisomerase I – DNA Complex

BACKGROUND: Human topoisomerase I catalyzes the relaxation of DNA supercoils in fundamental cell processes like transcription, replication and chromosomal segregation. It is the only target of the camptothecin family of anticancer drugs. Among these, topotecan has been used to treat lung and ovarian...

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Detalles Bibliográficos
Autores principales:	Mancini, Giordano, D'Annessa, Ilda, Coletta, Andrea, Sanna, Nico, Chillemi, Giovanni, Desideri, Alessandro
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2880615/ https://www.ncbi.nlm.nih.gov/pubmed/20532182 http://dx.doi.org/10.1371/journal.pone.0010934

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