Ganglioside synthase knockout in oncogene-transformed fibroblasts depletes gangliosides and impairs tumor growth

Biologically active membrane gangliosides, expressed and released by many human tumors, are hypothesized to significantly impact tumor progression. Lack of a model of complete and specific tumor ganglioside depletion in vivo, however, has hampered elucidation of their role. Here we report the creati...

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Detalles Bibliográficos
Autores principales: Liu, Yihui, Yan, Su, Wondimu, Assefa, Bob, Daniel, Weiss, Michael, Sliwinski, Konrad, Villar, Joaquín, Notario, Vicente, Sutherland, Margaret, Colberg-Poley, Anamaris M., Ladisch, Stephan
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2880627/
https://www.ncbi.nlm.nih.gov/pubmed/20305696
http://dx.doi.org/10.1038/onc.2010.85

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2880627/
https://www.ncbi.nlm.nih.gov/pubmed/20305696
http://dx.doi.org/10.1038/onc.2010.85

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