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Ganglioside synthase knockout in oncogene-transformed fibroblasts depletes gangliosides and impairs tumor growth
Biologically active membrane gangliosides, expressed and released by many human tumors, are hypothesized to significantly impact tumor progression. Lack of a model of complete and specific tumor ganglioside depletion in vivo, however, has hampered elucidation of their role. Here we report the creati...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2880627/ https://www.ncbi.nlm.nih.gov/pubmed/20305696 http://dx.doi.org/10.1038/onc.2010.85 |