Cargando…

A deficiency in Mdm2 binding protein (MTBP) inhibits Myc-induced B cell proliferation and lymphomagenesis

Mdm2 binding protein (MTBP) has been implicated in cell cycle arrest and the Mdm2-p53 tumor suppressor pathway through its interaction with Mdm2. To determine the function of MTBP in tumorigenesis and its potential role in the Mdm2-p53 pathway, we crossed Mtbp deficient mice to Eµ-myc transgenic mic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Odvody, Jessica, Vincent, Tiffaney, Arrate, Maria Pia, Grieb, Brian, Wang, Shuo, Garriga, Judit, Lozano, Guillermina, Iwakuma, Tomoo, Haines, Dale S., Eischen, Christine M.
Formato:	Texto
Lenguaje:	English
Publicado:	2010
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2880662/ https://www.ncbi.nlm.nih.gov/pubmed/20305689 http://dx.doi.org/10.1038/onc.2010.82

Ejemplares similares

MTBP and MYC: A Dynamic Duo in Proliferation, Cancer, and Aging
por: Grieb, Brian C., et al.
Publicado: (2022)

Haploinsufficiency of the Myc regulator Mtbp extends survival and delays tumor development in aging mice
por: Grieb, Brian C., et al.
Publicado: (2016)

MTBP suppresses cell migration and filopodia formation by inhibiting ACTN4
por: Agarwal, Neeraj, et al.
Publicado: (2012)

Characterization of an Mtbp Hypomorphic Allele in a Diethylnitrosamine-Induced Liver Carcinogenesis Model
por: Ranjan, Atul, et al.
Publicado: (2023)

MTBP inhibits the Erk1/2-Elk-1 signaling in hepatocellular carcinoma
por: Ranjan, Atul, et al.
Publicado: (2018)

Defective replication stress response inhibits lymphomagenesis and impairs lymphocyte reconstitution
por: Puccetti, Matthew V., et al.
Publicado: (2016)

Mdmx promotes genomic instability independent of p53 and Mdm2
por: Carrillo, Alexia M., et al.
Publicado: (2014)

Aging mice have increased chromosome instability that is exacerbated by elevated Mdm2 expression
por: Lushnikova, Tamara, et al.
Publicado: (2011)

Mnt modulates Myc-driven lymphomagenesis
por: Campbell, Kirsteen J, et al.
Publicado: (2017)

Role of MYC in B Cell Lymphomagenesis
por: Korać, Petra, et al.
Publicado: (2017)

Myc suppression of Nfkb2 accelerates lymphomagenesis
por: Keller, Ulrich, et al.
Publicado: (2010)

Max deletion destabilizes MYC protein and abrogates Eµ-Myc lymphomagenesis
por: Mathsyaraja, Haritha, et al.
Publicado: (2019)

FoxO3 suppresses Myc-driven lymphomagenesis
por: Vandenberg, C J, et al.
Publicado: (2016)

Ubiquitination of mammalian AP endonuclease (APE1) regulated by the p53-MDM2 signaling pathway
por: Busso, Carlos S., et al.
Publicado: (2009)

A novel link between the HER2-Akt and MDM2-p53 pathways via CSN6
por: Iyer, Swathi V., et al.
Publicado: (2012)

Myc Oncogene-Induced Genomic Instability: DNA Palindromes in Bursal Lymphomagenesis
por: Neiman, Paul E., et al.
Publicado: (2008)

MTBP phosphorylation controls DNA replication origin firing
por: Ferreira, Pedro, et al.
Publicado: (2021)

The Role of MTBP as a Replication Origin Firing Factor
por: Zaffar, Eman, et al.
Publicado: (2022)

Role of Mdm2 and Mdmx in DNA repair
por: Eischen, Christine M.
Publicado: (2017)

Insights about MYC and Apoptosis in B-Lymphomagenesis: An Update from Murine Models
por: Vecchio, Eleonora, et al.
Publicado: (2020)

Polycomb group ring finger protein 6 suppresses Myc-induced lymphomagenesis
por: Tanaskovic, Nina, et al.
Publicado: (2022)

Deletion of the transcriptional regulator TFAP4 accelerates c-MYC-driven lymphomagenesis
por: Potts, Margaret A., et al.
Publicado: (2023)

A Role for E2F Activities in Determining the Fate of Myc-Induced Lymphomagenesis
por: Rempel, Rachel E., et al.
Publicado: (2009)

The IgH 3′ regulatory region influences lymphomagenesis in Igλ-Myc mice
por: Saad, Faten, et al.
Publicado: (2015)

The IgH 3’ regulatory region and c-myc-induced B-cell lymphomagenesis
por: Ghazzaui, Nour, et al.
Publicado: (2016)

Germinal Centre B Cell Functions and Lymphomagenesis: Circuits Involving MYC and MicroRNAs
por: Robaina, Marcela Cristina, et al.
Publicado: (2019)

Dichotomous Impact of Myc on rRNA Gene Activation and Silencing in B Cell Lymphomagenesis
por: Joshi, Gaurav, et al.
Publicado: (2020)

IL-6 promotes MYC-induced B cell lymphomagenesis independent of STAT3
por: Petrenko, Oleksi, et al.
Publicado: (2021)

Long Non-Coding RNA CRYBG3 Promotes Lung Cancer Metastasis via Activating the eEF1A1/MDM2/MTBP Axis
por: Wu, Anqing, et al.
Publicado: (2021)

Mdm proteins: critical regulators of embryogenesis and homoeostasis
por: Moyer, Sydney M., et al.
Publicado: (2017)

Immunosenescence and lymphomagenesis
por: Mancuso, Salvatrice, et al.
Publicado: (2018)

EBV and Lymphomagenesis
por: Sausen, Daniel G., et al.
Publicado: (2023)

Burkitt lymphomagenesis linked to MYC plus PI3K in germinal center B cells
por: Sander, Sandrine, et al.
Publicado: (2012)

Cellular redox homeostasis maintained by malic enzyme 2 is essential for MYC-driven T cell lymphomagenesis
por: Li, Wei, et al.
Publicado: (2023)

Multiple monoclonal B cell expansions and c-myc oncogene rearrangements in acquired immune deficiency syndrome-related lymphoproliferative disorders. Implications for lymphomagenesis
Publicado: (1986)

MTBP regulates cell survival and therapeutic sensitivity in TP53 wildtype glioblastomas
por: Song, Yifu, et al.
Publicado: (2019)

The TRESLIN-MTBP complex couples completion of DNA replication with S/G2 transition
por: Zonderland, Gijs, et al.
Publicado: (2022)

Critical B-lymphoid cell intrinsic role of endogenous MCL-1 in c-MYC-induced lymphomagenesis
por: Grabow, S, et al.
Publicado: (2016)

The class-specific BCR tonic signal modulates lymphomagenesis in a c-myc deregulation transgenic model
por: Amin, Rada, et al.
Publicado: (2014)

IBTK contributes to B-cell lymphomagenesis in Eμ-myc transgenic mice conferring resistance to apoptosis
por: Vecchio, Eleonora, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_k53nlnlp17fk3f8r3i0se05ank