Proarrhythmia Induced by Propafenone: What is the Mechanism?

Propafenone, a Class IC antiarrhythmic drug, is an orally active sodium channel-blocking agent. It is effective in supraventricular tachyarrhythmias and is particularly useful in converting atrial fibrillation to sinus rhythm. In therapeutic doses, it may cause non-cardiac and cardiac toxicity, incl...

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Detalles Bibliográficos
Autores principales: Femenia, Francisco, Palazzolo, Jorge, Arce, Mauricio, Arrieta, Martin
Formato: Texto
Lenguaje:English
Publicado: Indian Heart Rhythm Society 2010
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2880874/
https://www.ncbi.nlm.nih.gov/pubmed/20552063
Descripción
Sumario:Propafenone, a Class IC antiarrhythmic drug, is an orally active sodium channel-blocking agent. It is effective in supraventricular tachyarrhythmias and is particularly useful in converting atrial fibrillation to sinus rhythm. In therapeutic doses, it may cause non-cardiac and cardiac toxicity, including proarrhythmia.

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