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Snazer: the simulations and networks analyzer

BACKGROUND: Networks are widely recognized as key determinants of structure and function in systems that span the biological, physical, and social sciences. They are static pictures of the interactions among the components of complex systems. Often, much effort is required to identify networks as pa...

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Detalles Bibliográficos
Autores principales: Mazza, Tommaso, Iaccarino, Gennaro, Priami, Corrado
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2880970/
https://www.ncbi.nlm.nih.gov/pubmed/20056001
http://dx.doi.org/10.1186/1752-0509-4-1
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author Mazza, Tommaso
Iaccarino, Gennaro
Priami, Corrado
author_facet Mazza, Tommaso
Iaccarino, Gennaro
Priami, Corrado
author_sort Mazza, Tommaso
collection PubMed
description BACKGROUND: Networks are widely recognized as key determinants of structure and function in systems that span the biological, physical, and social sciences. They are static pictures of the interactions among the components of complex systems. Often, much effort is required to identify networks as part of particular patterns as well as to visualize and interpret them. From a pure dynamical perspective, simulation represents a relevant way-out. Many simulator tools capitalized on the "noisy" behavior of some systems and used formal models to represent cellular activities as temporal trajectories. Statistical methods have been applied to a fairly large number of replicated trajectories in order to infer knowledge. A tool which both graphically manipulates reactive models and deals with sets of simulation time-course data by aggregation, interpretation and statistical analysis is missing and could add value to simulators. RESULTS: We designed and implemented Snazer, the simulations and networks analyzer. Its goal is to aid the processes of visualizing and manipulating reactive models, as well as to share and interpret time-course data produced by stochastic simulators or by any other means. CONCLUSIONS: Snazer is a solid prototype that integrates biological network and simulation time-course data analysis techniques.
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spelling pubmed-28809702010-06-05 Snazer: the simulations and networks analyzer Mazza, Tommaso Iaccarino, Gennaro Priami, Corrado BMC Syst Biol Software BACKGROUND: Networks are widely recognized as key determinants of structure and function in systems that span the biological, physical, and social sciences. They are static pictures of the interactions among the components of complex systems. Often, much effort is required to identify networks as part of particular patterns as well as to visualize and interpret them. From a pure dynamical perspective, simulation represents a relevant way-out. Many simulator tools capitalized on the "noisy" behavior of some systems and used formal models to represent cellular activities as temporal trajectories. Statistical methods have been applied to a fairly large number of replicated trajectories in order to infer knowledge. A tool which both graphically manipulates reactive models and deals with sets of simulation time-course data by aggregation, interpretation and statistical analysis is missing and could add value to simulators. RESULTS: We designed and implemented Snazer, the simulations and networks analyzer. Its goal is to aid the processes of visualizing and manipulating reactive models, as well as to share and interpret time-course data produced by stochastic simulators or by any other means. CONCLUSIONS: Snazer is a solid prototype that integrates biological network and simulation time-course data analysis techniques. BioMed Central 2010-01-07 /pmc/articles/PMC2880970/ /pubmed/20056001 http://dx.doi.org/10.1186/1752-0509-4-1 Text en Copyright ©2010 Mazza et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Software
Mazza, Tommaso
Iaccarino, Gennaro
Priami, Corrado
Snazer: the simulations and networks analyzer
title Snazer: the simulations and networks analyzer
title_full Snazer: the simulations and networks analyzer
title_fullStr Snazer: the simulations and networks analyzer
title_full_unstemmed Snazer: the simulations and networks analyzer
title_short Snazer: the simulations and networks analyzer
title_sort snazer: the simulations and networks analyzer
topic Software
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2880970/
https://www.ncbi.nlm.nih.gov/pubmed/20056001
http://dx.doi.org/10.1186/1752-0509-4-1
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