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LINE-1 methylation is inherited in familial testicular cancer kindreds

BACKGROUND: Testicular germ cell tumors (TGCT) are the most frequent cancers among young men. There is a clear familial component to TGCT etiology, but no high-penetrance susceptibility gene has been identified. Epigenetic aberrations of the genome represent an alternative mechanism for cancer susce...

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Detalles Bibliográficos
Autores principales: Mirabello, Lisa, Savage, Sharon A, Korde, Larissa, Gadalla, Shahinaz M, Greene, Mark H
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2880977/
https://www.ncbi.nlm.nih.gov/pubmed/20478068
http://dx.doi.org/10.1186/1471-2350-11-77