Dimethylfumarate inhibits microglial and astrocytic inflammation by suppressing the synthesis of nitric oxide, IL-1β, TNF-α and IL-6 in an in-vitro model of brain inflammation

BACKGROUND: Brain inflammation plays a central role in multiple sclerosis (MS). Dimethylfumarate (DMF), the main ingredient of an oral formulation of fumaric acid esters with proven therapeutic efficacy in psoriasis, has recently been found to ameliorate the course of relapsing-remitting MS. Glial c...

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Detalles Bibliográficos
Autores principales: Wilms, Henrik, Sievers, Jobst, Rickert, Uta, Rostami-Yazdi, Martin, Mrowietz, Ulrich, Lucius, Ralph
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2880998/
https://www.ncbi.nlm.nih.gov/pubmed/20482831
http://dx.doi.org/10.1186/1742-2094-7-30

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