Cargando…

Effects of phosphodiesterase 4 inhibition on bleomycin-induced pulmonary fibrosis in mice

BACKGROUND: Pulmonary fibrosis (PF) is a group of devastating and largely irreversible diseases. Phosphodiesterase (PDE) 4 is involved in the processes of remodeling and inflammation, which play key role in tissue fibrosis. The aim of the study was, therefore, to investigate the effect of PDE4 inhib...

Descripción completa

Detalles Bibliográficos
Autores principales:	Udalov, Sergey, Dumitrascu, Rio, Pullamsetti, Soni S, Al-tamari, Hamza M, Weissmann, Norbert, Ghofrani, Hossein A, Guenther, Andreas, Voswinckel, Robert, Seeger, Werner, Grimminger, Friedrich, Schermuly, Ralph T
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2010
Materias:	Research article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2881047/ https://www.ncbi.nlm.nih.gov/pubmed/20444277 http://dx.doi.org/10.1186/1471-2466-10-26

Ejemplares similares

Correction to: Effects of phosphodiesterase 4 inhibition on bleomycin-induced pulmonary fibrosis in mice
por: Udalov, Sergey, et al.
Publicado: (2022)

Phosphodiesterase 6 subunits are expressed and altered in idiopathic pulmonary fibrosis
por: Nikolova, Sevdalina, et al.
Publicado: (2010)

Correction to: Phosphodiesterase 6 subunits are expressed and altered in idiopathic pulmonary fibrosis
por: Nikolova, Sevdalina, et al.
Publicado: (2022)

Phosphodiesterase 10A Upregulation Contributes to Pulmonary Vascular Remodeling
por: Tian, Xia, et al.
Publicado: (2011)

Characterization of a murine model of monocrotaline pyrrole-induced acute lung injury
por: Dumitrascu, Rio, et al.
Publicado: (2008)

Lung vasodilatory response to inhaled iloprost in experimental pulmonary hypertension: amplification by different type phosphodiesterase inhibitors
por: Schermuly, Ralph Theo, et al.
Publicado: (2005)

Cigarette Smoke-Induced Emphysema and Pulmonary Hypertension Can Be Prevented by Phosphodiesterase 4 and 5 Inhibition in Mice
por: Seimetz, Michael, et al.
Publicado: (2015)

Hypoxic pulmonary hypertension in mice with constitutively active platelet-derived growth factor receptor-β
por: Dahal, Bhola K., et al.
Publicado: (2011)

Inhaled tolafentrine reverses pulmonary vascular remodeling via inhibition of smooth muscle cell migration
por: Pullamsetti, Soni, et al.
Publicado: (2005)

Glycogen Synthase Kinase 3beta Contributes to Proliferation of Arterial Smooth Muscle Cells in Pulmonary Hypertension
por: Sklepkiewicz, Piotr, et al.
Publicado: (2011)

Iloprost-induced desensitization of the prostacyclin receptor in isolated rabbit lungs
por: Schermuly, Ralph T, et al.
Publicado: (2007)

Reply to Bogaard et al.: Emphysema Is—at the Most—Only a Mild Phenotype in the Sugen/Hypoxia Rat Model of Pulmonary Arterial Hypertension
por: Kojonazarov, Baktybek, et al.
Publicado: (2019)

Effects of riociguat in severe experimental pulmonary hypertension
por: Kojonazarov, Baktybek, et al.
Publicado: (2011)

The soluble guanylate cyclase stimulator riociguat ameliorates pulmonary hypertension induced by hypoxia and SU5416 in rats
por: Lang, Michaela, et al.
Publicado: (2011)

Diacylglycerol regulates acute hypoxic pulmonary vasoconstriction via TRPC6
por: Fuchs, Beate, et al.
Publicado: (2011)

Therapeutic Potential of Regorafenib—A Multikinase Inhibitor in Pulmonary Hypertension
por: Veeroju, Swathi, et al.
Publicado: (2021)

sGC activators and stimulators attenuate ischemia/reperfusion injury of the lung
por: Egemnazarov, Bakytbek, et al.
Publicado: (2009)

Effects of macitentan and tadalafil monotherapy or their combination on the right ventricle and plasma metabolites in pulmonary hypertensive rats
por: Mamazhakypov, Argen, et al.
Publicado: (2020)

Effects of hypercapnia and NO synthase inhibition in sustained hypoxic pulmonary vasoconstriction
por: Ketabchi, Farzaneh, et al.
Publicado: (2012)

Nebulization of the acidified sodium nitrite formulation attenuates acute hypoxic pulmonary vasoconstriction
por: Egemnazarov, Bakytbek, et al.
Publicado: (2010)

Targeting cyclin-dependent kinases for the treatment of pulmonary arterial hypertension
por: Weiss, Astrid, et al.
Publicado: (2019)

Air travel can be safe and well tolerated in patients with clinically stable pulmonary hypertension
por: Thamm, Melanie, et al.
Publicado: (2011)

Improvement of right heart structure and function by BAY 41-8543 in pulmonary artery banded mice
por: Janssen, Wiebke, et al.
Publicado: (2011)

Correction: Improvement of right heart structure and function by BAY41-8543 in pulmonary artery banded mice
por: Janssen, Wiebke, et al.
Publicado: (2011)

The Soluble Guanylate Cyclase Stimulator Riociguat Ameliorates Pulmonary Hypertension Induced by Hypoxia and SU5416 in Rats
por: Lang, Michaela, et al.
Publicado: (2012)

Retraction: Nitric Oxide Synthase 2 Induction Promotes Right Ventricular Fibrosis
por: Boehm, Mario, et al.
Publicado: (2022)

IRAG1 Deficient Mice Develop PKG1β Dependent Pulmonary Hypertension
por: Biswas, Siladitta, et al.
Publicado: (2020)

Detection of reactive oxygen species in isolated, perfused lungs by electron spin resonance spectroscopy
por: Weissmann, Norbert, et al.
Publicado: (2005)

FoxO3 an important player in fibrogenesis and therapeutic target for idiopathic pulmonary fibrosis
por: Al‐Tamari, Hamza M, et al.
Publicado: (2017)

5-HT2B Receptor Antagonists Inhibit Fibrosis and Protect from RV Heart Failure
por: Janssen, Wiebke, et al.
Publicado: (2015)

Smoking: Is it a risk factor for pulmonary vascular diseases?
por: Weissmann, Norbert, et al.
Publicado: (2012)

Involvement of mast cells in monocrotaline-induced pulmonary hypertension in rats
por: Dahal, Bhola K, et al.
Publicado: (2011)

Chronic intratracheal application of the soluble guanylyl cyclase stimulator BAY 41-8543 ameliorates experimental pulmonary hypertension
por: Amirjanians, Matthieu, et al.
Publicado: (2017)

Effects of Multikinase inhibitors on pressure overload-induced right ventricular remodelling
por: Kojonazarov, Baktybek, et al.
Publicado: (2013)

Eplerenone attenuates pathological pulmonary vascular rather than right ventricular remodeling in pulmonary arterial hypertension
por: Boehm, Mario, et al.
Publicado: (2018)

Genetic Deficiency and Pharmacological Stabilization of Mast Cells Ameliorate Pressure Overload-Induced Maladaptive Right Ventricular Remodeling in Mice
por: Sydykov, Akylbek, et al.
Publicado: (2020)

Correction to: Eplerenone attenuates pathological pulmonary vascular rather than right ventricular remodeling in pulmonary arterial hypertension
por: Boehm, Mario, et al.
Publicado: (2022)

Mechanisms of disease: pulmonary arterial hypertension
por: Schermuly, Ralph T., et al.
Publicado: (2011)

Therapeutic efficacy of TBC3711 in monocrotaline-induced pulmonary hypertension
por: Kosanovic, Djuro, et al.
Publicado: (2011)

Pressure overload leads to an increased accumulation and activity of mast cells in the right ventricle
por: Luitel, Himal, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_aol4tp1n4ujcbgccdi1tgue85f