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Effect of Propranolol on Functional Connectivity in Autism Spectrum Disorder—A Pilot Study
A decrease in interaction between brain regions is observed in individuals with autism spectrum disorder (ASD), which is believed to be related to restricted neural network access in ASD. Propranolol, a beta-adrenergic antagonist, has revealed benefit during performance of tasks involving flexibilit...
Autores principales: | , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Springer-Verlag
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2881209/ https://www.ncbi.nlm.nih.gov/pubmed/20502989 http://dx.doi.org/10.1007/s11682-010-9098-8 |
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author | Narayanan, Ananth White, Catherine A. Saklayen, Sanjida Scaduto, Mary J. Carpenter, Allen L. Abduljalil, Amir Schmalbrock, Petra Beversdorf, David Q. |
author_facet | Narayanan, Ananth White, Catherine A. Saklayen, Sanjida Scaduto, Mary J. Carpenter, Allen L. Abduljalil, Amir Schmalbrock, Petra Beversdorf, David Q. |
author_sort | Narayanan, Ananth |
collection | PubMed |
description | A decrease in interaction between brain regions is observed in individuals with autism spectrum disorder (ASD), which is believed to be related to restricted neural network access in ASD. Propranolol, a beta-adrenergic antagonist, has revealed benefit during performance of tasks involving flexibility of access to networks, a benefit also seen in ASD. Our goal was to determine the effect of propranolol on functional connectivity in ASD during a verbal decision making task as compared to nadolol, thereby accounting for the potential spurious fMRI effects due to peripheral hemodynamic effects of propranolol. Ten ASD subjects underwent fMRI scans after administration of placebo, propranolol or nadolol, while performing a phonological decision making task. Comparison of functional connectivity between pre-defined ROI-pairs revealed a significant increase with propranolol compared to nadolol, suggesting a potential imaging marker for the cognitive effects of propranolol in ASD. |
format | Text |
id | pubmed-2881209 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Springer-Verlag |
record_format | MEDLINE/PubMed |
spelling | pubmed-28812092010-06-10 Effect of Propranolol on Functional Connectivity in Autism Spectrum Disorder—A Pilot Study Narayanan, Ananth White, Catherine A. Saklayen, Sanjida Scaduto, Mary J. Carpenter, Allen L. Abduljalil, Amir Schmalbrock, Petra Beversdorf, David Q. Brain Imaging Behav Article A decrease in interaction between brain regions is observed in individuals with autism spectrum disorder (ASD), which is believed to be related to restricted neural network access in ASD. Propranolol, a beta-adrenergic antagonist, has revealed benefit during performance of tasks involving flexibility of access to networks, a benefit also seen in ASD. Our goal was to determine the effect of propranolol on functional connectivity in ASD during a verbal decision making task as compared to nadolol, thereby accounting for the potential spurious fMRI effects due to peripheral hemodynamic effects of propranolol. Ten ASD subjects underwent fMRI scans after administration of placebo, propranolol or nadolol, while performing a phonological decision making task. Comparison of functional connectivity between pre-defined ROI-pairs revealed a significant increase with propranolol compared to nadolol, suggesting a potential imaging marker for the cognitive effects of propranolol in ASD. Springer-Verlag 2010-05-20 2010 /pmc/articles/PMC2881209/ /pubmed/20502989 http://dx.doi.org/10.1007/s11682-010-9098-8 Text en © The Author(s) 2010 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. |
spellingShingle | Article Narayanan, Ananth White, Catherine A. Saklayen, Sanjida Scaduto, Mary J. Carpenter, Allen L. Abduljalil, Amir Schmalbrock, Petra Beversdorf, David Q. Effect of Propranolol on Functional Connectivity in Autism Spectrum Disorder—A Pilot Study |
title | Effect of Propranolol on Functional Connectivity in Autism Spectrum Disorder—A Pilot Study |
title_full | Effect of Propranolol on Functional Connectivity in Autism Spectrum Disorder—A Pilot Study |
title_fullStr | Effect of Propranolol on Functional Connectivity in Autism Spectrum Disorder—A Pilot Study |
title_full_unstemmed | Effect of Propranolol on Functional Connectivity in Autism Spectrum Disorder—A Pilot Study |
title_short | Effect of Propranolol on Functional Connectivity in Autism Spectrum Disorder—A Pilot Study |
title_sort | effect of propranolol on functional connectivity in autism spectrum disorder—a pilot study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2881209/ https://www.ncbi.nlm.nih.gov/pubmed/20502989 http://dx.doi.org/10.1007/s11682-010-9098-8 |
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