Cargando…

Effects of TLR Agonists on the Hypoxia-Regulated Transcription Factor HIF-1α and Dendritic Cell Maturation under Normoxic Conditions

Dendritic cells (DC) are professional antigen presenting cells that represent an important link between innate and adaptive immunity. Danger signals such as toll-like receptor (TLR) agonists induce maturation of DC leading to a T-cell mediated adaptive immune response. In this study, we show that ex...

Descripción completa

Detalles Bibliográficos
Autores principales:	Spirig, Rolf, Djafarzadeh, Siamak, Regueira, Tomas, Shaw, Sidney G., von Garnier, Christophe, Takala, Jukka, Jakob, Stephan M., Rieben, Robert, Lepper, Philipp M.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2881864/ https://www.ncbi.nlm.nih.gov/pubmed/20539755 http://dx.doi.org/10.1371/journal.pone.0010983

Ejemplares similares

Induction of hypoxia inducible factor 1α by Toll-like receptors in human dendritic cells
por: Djafarzadeh, S, et al.
Publicado: (2008)

Endotoxin-induced activation of hypoxia-inducible factor 1α in cultured human hepatocytes and monocytes: impact on cellular and mitochondrial respiration
por: Regueira, T, et al.
Publicado: (2008)

Norepinephrine to increase blood pressure in endotoxaemic pigs is associated with improved hepatic mitochondrial respiration
por: Regueira, Tomas, et al.
Publicado: (2008)

Noradrenaline for treatment of endotoxemic shock in pigs is associated with improved hepatic mitochondrial respiration
por: Regueira, T, et al.
Publicado: (2008)

Effect of Remifentanil on Mitochondrial Oxygen Consumption of Cultured Human Hepatocytes
por: Djafarzadeh, Siamak, et al.
Publicado: (2012)

Correction: Effect of Remifentanil on Mitochondrial Oxygen Consumption of Cultured Human Hepatocytes
por: Djafarzadeh, Siamak, et al.
Publicado: (2012)

The Emerging Role of TLR and Innate Immunity in Cardiovascular Disease
por: Spirig, Rolf, et al.
Publicado: (2012)

Dose Response of Endotoxin on Hepatocyte and Muscle Mitochondrial Respiration In Vitro
por: Jeger, Victor, et al.
Publicado: (2015)

Increasing mean arterial blood pressure in sepsis: effects on fluid balance, vasopressor load and renal function
por: Corrêa, Thiago Domingos, et al.
Publicado: (2013)

Effect of fluid resuscitation on mortality and organ function in experimental sepsis models
por: Brandt, Sebastian, et al.
Publicado: (2009)

Time course of blood lactate levels, inflammation, and mitochondrial function in experimental sepsis
por: Corrêa, Thiago Domingos, et al.
Publicado: (2017)

Different Contribution of Splanchnic Organs to Hyperlactatemia in Fecal Peritonitis and Cardiac Tamponade
por: Gorrasi, José, et al.
Publicado: (2013)

Mitochondrial function of immune cells in septic shock: A prospective observational cohort study
por: Merz, Tobias M., et al.
Publicado: (2017)

Effects of volume resuscitation on hepatosplanchnic oxygen consumption, liver mitochondrial function and mortality in endotoxemia
por: Regueira, T, et al.
Publicado: (2007)

Causes and Consequences of A Glutamine Induced Normoxic HIF1 Activity for the Tumor Metabolism
por: Kappler, Matthias, et al.
Publicado: (2019)

TLR4 Agonist and Hypoxia Synergistically Promote the Formation of TLR4/NF-κB/HIF-1α Loop in Human Epithelial Ovarian Cancer
por: Zhao, Bin, et al.
Publicado: (2022)

Effects of lipopolysaccharide on isolated muscle mitochondrial respiration are dose and time dependent
por: Brandt, S, et al.
Publicado: (2010)

Hypoxia Inducible Factor (HIF)-1 Coordinates Induction of Toll-Like Receptors TLR2 and TLR6 during Hypoxia
por: Kuhlicke, Johannes, et al.
Publicado: (2007)

Early changes of muscle membrane properties in porcine faecal peritonitis
por: Ackermann, Karin A, et al.
Publicado: (2014)

Involvement of mitochondrial ATP-sensitive K(+ )channels in fentanyl-induced mitochondrial dysfunction of cultured human hepatocytes
por: Djafarzadeh, S, et al.
Publicado: (2013)

The LINK-A lncRNA Activates Normoxic HIF1α Signaling in Triple-negative Breast Cancer
por: Lin, Aifu, et al.
Publicado: (2016)

Liposomal TLR9 Agonist Combined with TLR2 Agonist-Fused Antigen Can Modulate Tumor Microenvironment through Dendritic Cells
por: Shen, Kuan-Yin, et al.
Publicado: (2020)

Korean Red Ginseng-Induced SIRT3 Promotes the Tom22–HIF-1α Circuit in Normoxic Astrocytes
por: Kim, Hyungsu, et al.
Publicado: (2023)

The combination of TLR2 and TLR4 agonists promotes the immunogenicity of dendritic cell/cancer cell fusions
por: Koido, Shigeo, et al.
Publicado: (2013)

Reconstituted High-Density Lipoprotein Modulates Activation of Human Leukocytes
por: Spirig, Rolf, et al.
Publicado: (2013)

Effects of Normoxic Recovery on Intima-Media Thickness of Aorta and Pulmonary Artery Following Intermittent Hypoxia in Mice
por: Umeda, Akira, et al.
Publicado: (2020)

Transcriptional networks in plasmacytoid dendritic cells stimulated with synthetic TLR 7 agonists
por: Birmachu, Woubalem, et al.
Publicado: (2007)

Hif-1α Knockdown Reduces Glycolytic Metabolism and Induces Cell Death of Human Synovial Fibroblasts Under Normoxic Conditions
por: Del Rey, Manuel J., et al.
Publicado: (2017)

Normoxic HIF-1α Stabilization Caused by Local Inflammatory Factors and Its Consequences in Human Coronary Artery Endothelial Cells
por: Abdi Sarabi, Mohsen, et al.
Publicado: (2022)

Norepinephrine versus angiotensin II in septic shock: effects on isolated kidney, heart and liver mitochondrial respiration
por: Jeger, V, et al.
Publicado: (2012)

Comparisons Between Normobaric Normoxic and Hypoxic Recovery on Post-exercise Hemodynamics After Sprint Interval Cycling in Hypoxia
por: Horiuchi, Masahiro, et al.
Publicado: (2022)

Lipopolysaccharide induces mitochondrial dysfunction in rat cardiac microvascular endothelial cells
por: Vuda, M, et al.
Publicado: (2011)

Hemodynamic and mitochondrial effects of enalapril in experimental sepsis
por: Pereira, AJ, et al.
Publicado: (2013)

Trichostatin A resistance is facilitated by HIF-1α acetylation in HeLa human cervical cancer cells under normoxic conditions
por: Lee, Jae-Wook, et al.
Publicado: (2017)

Regional venous–arterial CO(2) to arterial–venous O(2) content difference ratio in experimental circulatory shock and hypoxia
por: Corrêa, Thiago Domingos, et al.
Publicado: (2020)

Chromobox Homolog 4 is Positively Correlated to Tumor Growth, Survival and Activation of HIF-1α Signaling in Human Osteosarcoma under Normoxic Condition
por: Yang, Jielai, et al.
Publicado: (2016)

TRIF Is a Critical Negative Regulator of TLR Agonist Mediated Activation of Dendritic Cells In Vivo
por: Seregin, Sergey S., et al.
Publicado: (2011)

Supraspinal fatigue after normoxic and hypoxic exercise in humans
por: Goodall, Stuart, et al.
Publicado: (2012)

Normoxic and Hyperoxic Cardiopulmonary Bypass in Congenital Heart Disease
por: Mokhtari, Amir, et al.
Publicado: (2014)

Survivin expression pattern in the intestine of normoxic and ischemic rats
por: Scheer, Alexandra, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_1f3saejv473l7mlipa539ti4rv