Non-long terminal repeat (non-LTR) retrotransposons: mechanisms, recent developments, and unanswered questions

Non-long terminal repeat (non-LTR) retrotransposons are present in most eukaryotic genomes. In some species, such as humans, these elements are the most abundant genome sequence and continue to replicate to this day, creating a source of endogenous mutations and potential genotoxic stress. This revi...

Descripción completa

Detalles Bibliográficos
Autor principal: Han, Jeffrey S
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2881922/
https://www.ncbi.nlm.nih.gov/pubmed/20462415
http://dx.doi.org/10.1186/1759-8753-1-15
_version_ 1782182151832207360
author Han, Jeffrey S
author_facet Han, Jeffrey S
author_sort Han, Jeffrey S
collection PubMed
description Non-long terminal repeat (non-LTR) retrotransposons are present in most eukaryotic genomes. In some species, such as humans, these elements are the most abundant genome sequence and continue to replicate to this day, creating a source of endogenous mutations and potential genotoxic stress. This review will provide a general outline of the replicative cycle of non-LTR retrotransposons. Recent findings regarding the host regulation of non-LTR retrotransposons will be summarized. Finally, future directions of interest will be discussed.
format Text
id pubmed-2881922
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-28819222010-06-08 Non-long terminal repeat (non-LTR) retrotransposons: mechanisms, recent developments, and unanswered questions Han, Jeffrey S Mob DNA Review Non-long terminal repeat (non-LTR) retrotransposons are present in most eukaryotic genomes. In some species, such as humans, these elements are the most abundant genome sequence and continue to replicate to this day, creating a source of endogenous mutations and potential genotoxic stress. This review will provide a general outline of the replicative cycle of non-LTR retrotransposons. Recent findings regarding the host regulation of non-LTR retrotransposons will be summarized. Finally, future directions of interest will be discussed. BioMed Central 2010-05-12 /pmc/articles/PMC2881922/ /pubmed/20462415 http://dx.doi.org/10.1186/1759-8753-1-15 Text en Copyright ©2010 Han; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Han, Jeffrey S
Non-long terminal repeat (non-LTR) retrotransposons: mechanisms, recent developments, and unanswered questions
title Non-long terminal repeat (non-LTR) retrotransposons: mechanisms, recent developments, and unanswered questions
title_full Non-long terminal repeat (non-LTR) retrotransposons: mechanisms, recent developments, and unanswered questions
title_fullStr Non-long terminal repeat (non-LTR) retrotransposons: mechanisms, recent developments, and unanswered questions
title_full_unstemmed Non-long terminal repeat (non-LTR) retrotransposons: mechanisms, recent developments, and unanswered questions
title_short Non-long terminal repeat (non-LTR) retrotransposons: mechanisms, recent developments, and unanswered questions
title_sort non-long terminal repeat (non-ltr) retrotransposons: mechanisms, recent developments, and unanswered questions
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2881922/
https://www.ncbi.nlm.nih.gov/pubmed/20462415
http://dx.doi.org/10.1186/1759-8753-1-15
work_keys_str_mv AT hanjeffreys nonlongterminalrepeatnonltrretrotransposonsmechanismsrecentdevelopmentsandunansweredquestions

Ejemplares similares