Application of simple fed-batch technique to high-level secretory production of insulin precursor using Pichia pastoris with subsequent purification and conversion to human insulin

BACKGROUND: The prevalence of diabetes is predicted to rise significantly in the coming decades. A recent analysis projects that by the year 2030 there will be ~366 million diabetics around the world, leading to an increased demand for inexpensive insulin to make this life-saving drug also affordabl...

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Detalles Bibliográficos
Autores principales: Gurramkonda, Chandrasekhar, Polez, Sulena, Skoko, Natasa, Adnan, Ahmad, Gäbel, Thomas, Chugh, Dipti, Swaminathan, Sathyamangalam, Khanna, Navin, Tisminetzky, Sergio, Rinas, Ursula
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2882349/
https://www.ncbi.nlm.nih.gov/pubmed/20462406
http://dx.doi.org/10.1186/1475-2859-9-31

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2882349/
https://www.ncbi.nlm.nih.gov/pubmed/20462406
http://dx.doi.org/10.1186/1475-2859-9-31

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