Rapamycin Pharmacokinetic and Pharmacodynamic Relationships in Osteosarcoma: A Comparative Oncology Study in Dogs

BACKGROUND: Signaling through the mTOR pathway contributes to growth, progression and chemoresistance of several cancers. Accordingly, inhibitors have been developed as potentially valuable therapeutics. Their optimal development requires consideration of dose, regimen, biomarkers and a rationale fo...

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Detalles Bibliográficos
Autores principales: Paoloni, Melissa C., Mazcko, Christina, Fox, Elizabeth, Fan, Timothy, Lana, Susan, Kisseberth, William, Vail, David M., Nuckolls, Kaylee, Osborne, Tanasa, Yalkowsy, Samuel, Gustafson, Daniel, Yu, Yunkai, Cao, Liang, Khanna, Chand
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2882366/
https://www.ncbi.nlm.nih.gov/pubmed/20543980
http://dx.doi.org/10.1371/journal.pone.0011013

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