Dysregulation of the Norepinephrine Transporter Sustains Cortical Hypodopaminergia and Schizophrenia-Like Behaviors in Neuronal Rictor Null Mice

The mammalian target of rapamycin (mTOR) complex 2 (mTORC2) is a multimeric signaling unit that phosphorylates protein kinase B/Akt following hormonal and growth factor stimulation. Defective Akt phosphorylation at the mTORC2-catalyzed Ser473 site has been linked to schizophrenia. While human imagin...

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Detalles Bibliográficos
Autores principales: Siuta, Michael A., Robertson, Sabrina D., Kocalis, Heidi, Saunders, Christine, Gresch, Paul J., Khatri, Vivek, Shiota, Chiyo, Kennedy, J. Philip, Lindsley, Craig W., Daws, Lynette C., Polley, Daniel B., Veenstra-Vanderweele, Jeremy, Stanwood, Gregg D., Magnuson, Mark A., Niswender, Kevin D., Galli, Aurelio
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2882427/
https://www.ncbi.nlm.nih.gov/pubmed/20543991
http://dx.doi.org/10.1371/journal.pbio.1000393

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